Exploitation of genomic selection technologies in the UK sheep population

组学——开发新的工具和技术，以更好地获取、理解和利用基因组、转录组、蛋白质组和代谢组信息。该提案旨在通过由英国羊肉供应链和其他学科（如植物基因组学）的主要创新者组成的联盟开发和利用新的基因组技术，实现创新，从而提高英国绵羊部门高效和高产种畜的供应。由此产生的技术将能够在整个行业中应用，以便在整个英国部门进一步利用经济，社会和环境效益，并将提供可能应用于其他物种的重要新信息。该提案旨在以质量和规模产生复杂的基因组和表型信息，这在英国绵羊中从未尝试过。这将导致基因组育种值（gbv）的使用，这将使遗传改良更加困难，以改善目前无法容易、快速或廉价地在体内测量的性状。在这样做时，它符合呼叫权限如下：1。受基因组技术最新发展的启发，绵羊基因组的发表和能够识别绵羊2新生产性状的snp的开发。我们将努力在大量动物种群中使用大量已测量的性状来开发可用于应用这些技术的新工具，以便首次在英国的商业绵羊种群中加以利用。3. 将使用新的方法将特定的单倍型块和拷贝数变异与表型变异联系起来，这样做将支持未来绵羊SNP技术的发展。将在相同的成本基础上提高羊肉的产量和质量，从而支持整个羊肉供应链的经济增长和环境可持续性。将使Innovis和随后的英国羊产业利用基因组选择来保护其市场免受海外竞争。

'Omics - development of novel tools and techniques to better access, understand and enable the exploitaiton of genomic, transcriptomic, proteomic and metabolomic information. This proposal aims to enable innovations that will enhance the supply of more efficient and productive breeding stock to the UK sheep sector through the development and exploitation of new genomic technologies by a consortium comprising key innovators within the UK lamb supply chain and from other disciplines (e.g. plant genomics). The resulting technology will be capable of application throughout the Industry so that the economic, social, and environmental benefits can be further exploited across the UK sector and will provide important new information that may be applied in other speciesThe proposal aims to yield complex genomic and phenotypic information on a quality and scale that has not been attempted before in UK sheep. This will lead to the use of Genomic Breeding Values (GBVs) which will enable genetic improvement of the more difficult to improve traits that cannot currently be easily, quickly or cheaply measured in vivo. In doing so it fits with the call remit as it:1. Is inspired by the latest developments in genomic technologies following the publication of the sheep genome and development of SNPs capable of identifying new production traits in sheep 2. Will endeavour to use a very large number of measured traits in a large animal population to develop new tools that can be used to apply these technologies so that they can be exploited in commercial sheep populations in the UK for the first time. 3. Will use novel approaches to relate specific haplotype blocks and copy number variations to phenotypic variation and in doing so support the development of future sheep SNP technolgy.4. Will improve the yield and quality of lamb from the same cost base and in doing so support economic growth and environmental sustainability throughout the lamb supply chain5. Will enable Innovis and subsequently the UK sheep industry to utilise genomic selection to safeguard its markets against overseas competition.