RADIONUCLIDES: RADIATION DETECTION AND QUANTIFICATION

这项拟议工作的长期目标是优化性能和 Sprint II的功能，目的是更好地学习这两个 定量的静态和动态过程。这样做的目的是扩展 SPECT对功能成像的能力。要做到这一点，需要 本征探测器分辨率和线性度的改进、 光圈几何，更精确的图像重建算法，以及 更好地了解信息传输的性质 层析成像过程。 探测器的改进将通过蒙特卡罗建模来实现 通过扩展一维最大似然位置估计 到2维。 最优孔径设计将包括研究互信息和 重建图像的方差和偏差分析。 将为非标准图像开发高效的重建算法 Sprint II的采样几何体，包括衰减和散射 更正。最后，将互信息的应用扩展到 检测和辨别任务。

The long term goal of this proposed work is to optimize the performance and functionality of SPRINT II with the aim of being better able to study both static and dynamic processes quantitatively. The aim is to extend the capabilities of SPECT to functional imaging. To accomplish this requires improvements in intrinsic detector resolution and linearity, refinement in aperture geometry, more accurate image reconstruction algorithms, and a better understanding of the nature of information transfer in the tomographic imaging process. Detector improvements will be accomplished by means of Monte Carlo modeling and by extending the 1-dimensional maximum likelihood position estimation to 2-dimensions. Optimum aperture design will include a study of mutual information and analysis of variance and bias in reconstructed images. Efficient reconstruction algorithms will be developed for the non-standard sampling geometry of SPRINT II which will include attenuation and scatter correction. Finally, application of mutual information will be extended to detection and discrimination tasks.