13TSB SynBio Use of Synthetic Biology methods to enhance and optimise production of a novel antibiotic

Demuris拥有一系列由不同放线菌生产的新型抗生素。目前，主要分子是由一种不适合大规模发酵的生物产生的，而且化合物结构在药理学性质方面可能还不是最理想的。我们希望确定抗生素生产者基因簇，并重新设计它，以便在优化的底盘中生产基于委内瑞拉链霉菌（Sven）的放线菌天然产物。途径工程将用于产生先导抗生素的类似物，这将用于促进药物优化和知识产权保护

Demuris has a pipeline of novel antibiotics produced by a variety of different actinobacteria. The leading molecule is presently made by an organism that is not ideal for large scale fermentation, and the compound structure may not yet be optimal in terms of pharmacological properties. We wish to identify the antibiotic producer gene cluster and re-engineer it for production in an optimized chassis for production of actinobacterial natural products based on Streptomyces venezuelae (Sven). Pathway engineering will be used to generate analogues of the lead antibiotic, which will be used to facilitate drug optimization and IP protection