NMR RELAXATION TIMES OF ALKALI METAL IONS

~(23)Na成像肯定比质子成像有一些优势 诊断目的。为了使用这项技术，重要的是 了解决定~(23)Na驰豫时间的各种因素。它 对~(23)Na的弛豫进行了系统的研究 在生物组织中： A.找出导致23Na的细胞和体液的成分 放松一下。 B.用~(23)Na核磁共振表征正常组织和病理组织 松弛和信号强度。 要研究的系统是血液及其成分，脑脊液，培养 细胞、整个器官等灌流大鼠的心脏、腿部和大脑 大鼠，最后是各种肿瘤组织，植入小鼠和样本或 在外科手术中切除人类肿瘤。 为了获得这些数据，必须开发一些技术来 非均相体系中多组分弛豫时间的测量 在使用表面线圈的测量中。 因此，我们希望能够理解钠松弛在 并能够区分不同种类的生物组织 组织损伤，如水肿、缺血以及各种肿瘤和 他们的发展状况。

23Na imaging may have some advantages over proton imaging for certain diagnostic purposes. In order to use this technique it is important to understand the various factors determining the 23Na relaxation times. It is proposed here to perform a systematic investigation of 23Na relaxation in biological tissues: a. To find the components of cells and body fluids responsible for the 23Na relaxation. b. To characterize normal and pathological tissues by their 23Na NMR relaxation and signal intensities. The systems to be investigated are blood and its components, CSF, cultured cells, whole organs such perfused rat hearts and legs and brain of live rats and finally various tumorous tissues, implanted in mice and samples or human tumors removed in surgical operations. In order to obtain this data some techniques will have to be developed for the measurement of multicomponent relaxation times in heterogeneous systems and in measurements using surface coils. As a result we hope to be able to understand sodium relaxation in biological tissues and to be able to differentiate between various kinds of tissue damages such as edema, ischemia, as well as various tumors and the state of their development.