PHYSICAL BASIS FOR DIAGNOSTIC 19F MR IMAGING

该项目的目的是开发和研究物理 产生磁共振图像（MRI）所需的技术， 可以注射到血液中的氟化化合物。 一些 这些成分已经达到了血液的高度发展， 替代品，并且毒性远远低于用于治疗的任何其他造影剂。 放射线照相术或MRI。 然而，目前的氟MRI技术不是 能够产生血管系统的高质量解剖图像 在场强和扫描时间可能可接受的条件下 临床上;两个主要原因是大的NMR光谱宽度 化合物和由于血液流动而导致的信号损失。 我们 我建议探索标准MRI脉冲序列的几种修改 和图像重建数学，承诺克服这些问题， 局限性。 我们也将探讨其他氟成像的效用 化合物，作为诊断造影剂，这可能是不可接受的， 维持生命的血液替代品 将对各种方法进行评估 使用计算机模拟，使用1.4特斯拉的幻影实验， 研究MRI机器，并在使用大鼠的初步体内实验中， 兔子和猫 目标是开发一种技术， 直接应用于人体的氟血管造影术。 非血管造影 并会研究影像应用。

This project has the purpose of developing and studying the physical techniques needed for producing magnetic resonance images (MRI) of fluorinated compounds which can be injected into the bloodstream. Some such components have already reached a high state of development as blood substitutes, and are far less toxic than any other contrast agents used in radiography or MRI. Present fluorine MRI techniques, however, are not capable of producing high quality anatomic images of the vascular system under condition of field strength and scan time likely to be acceptable clinically; two of the primary reasons are the large NMR spectral widths of the compounds and the loss of signal due to the flow of the blood. We propose to explore several modifications of standard MRI pulse sequences and image reconstruction mathematics which promise to overcome these limitations. We also will explore the utility of imaging other fluorine compounds, as diagnostic contrast agents, which might not be acceptable as a life supporting blood substitutes. The various methods will be evaluated using computer simulation, experiments in phantoms using a 1.4 Tesla research MRI machine, and in preliminary in vivo experiments using rats, rabbits, and cats. The goal is to develop a technique which could be directly applied to fluorine angiography in humans. Non angiographic imaging applications will also be studied.