MULTINUCLEAR MRI OF TUMORS IN ANIMALS

动物肿瘤的多核 MRI

• 批准号: 3187241
• 负责人: PETER M JOSEPH
• 金额: $ 17.36万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1992-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3187241
• 关键词: diagnosis design /evaluation; fluorine; human therapy evaluation; inflammation; laboratory mouse; laboratory rat; magnetic resonance imaging; neoplasm /cancer blood supply; neoplasm /cancer radiodiagnosis; oxygen tension; respiratory oxygenation; sodium

The central goal is the development of new MRI techniques, or new combinations of established techniques, for distinguishing tumors from normal tissue or inflammation. This is an important clinical diagnostic problem when diagnosing or staging cancer. While conventional MRI can often detect tumors, it is often difficult to distinguish them from imflammation or edema. A secondary goal is relating MR images to tumor vascular patterns and tumor oxygenation. Tumor oxygenation is an important factor in determining the response to radiation therapy. These goals will be approached by combining the information obtained from images of protons, fluorine, and sodium. The proton images will be used for their anatomical detail. The fluorine images will be of fluorinated blood substitutes and will dilineate vascular anatomy and measure the vascular oxygen tension. The sodium images will be of endogenous sodium which in biological systems shows two components of T2 decay. Chemical shift reagents will be used to identify the intra and extracellular components. We will determine whether the short T2 component can be used to distinguish tumors from edema. The work will be done in a variety of animal tumors of known vascularity and radiosensitivity. If successful, the techniques can be transferred to human imaging and should lead to improved tumor diagnosis.

中心目标是开发新的MRI技术，或新的 结合已建立的技术，用于区分肿瘤， 正常组织或炎症。 这是重要的临床诊断 诊断或分期癌症时的问题。 虽然常规MRI可以 通常检测肿瘤，通常很难区分它们 炎症或水肿。 第二个目标是将MR图像与肿瘤血管模式和肿瘤 氧合 肿瘤氧合是决定肿瘤细胞增殖的重要因素。 对放射治疗的反应。 这些目标将通过结合从以下方面获得的信息来实现： 质子氟和钠的图像 质子图像将用于 因为它们的解剖细节。 氟图像将是氟化的 血液替代品，并将dilineate血管解剖和测量 血管氧分压 钠图像将是内源性钠 在生物系统中，它显示了T2衰变的两个组成部分。 化学 转移试剂将用于鉴定细胞内和细胞外 件. 我们将确定是否可以使用短T2组件 来区分肿瘤和水肿 这项工作将在各种已知血管分布的动物肿瘤中进行 和辐射敏感性。 如果成功，这些技术可以转移到 人类成像，并应改善肿瘤诊断。