MULTINUCLEAR MRI OF TUMORS IN ANIMALS

中心目标是开发新的核磁共振技术，或称新的 现有技术的组合，用于区分肿瘤和 正常组织或炎症。这是一项重要的临床诊断 诊断或分期癌症时的问题。虽然传统的磁共振成像可以 经常检测到肿瘤，通常很难与 炎症或水肿症。 第二个目标是将磁共振图像与肿瘤血管类型和肿瘤联系起来。 氧合作用。肿瘤氧合是决定肿瘤预后的重要因素。 对放射治疗的反应。 这些目标将通过结合从以下方面获得的信息来实现 质子、氟和钠的图像。将使用质子图像 因为它们的解剖细节。氟图像将是经过氟化处理的 血液替代并将扩张血管解剖并测量 血管氧分压。钠的图像将是内源性的钠 它在生物系统中显示了T2衰变的两个成分。化学制品 将使用移位试剂来识别细胞内和细胞外 组件。我们将确定是否可以使用短T2分量 以区分肿瘤和水肿症。 这项工作将在各种已知有血管的动物肿瘤中进行 以及对辐射的敏感性。如果成功，这些技术可以转移到 人体成像，并应导致改进的肿瘤诊断。

The central goal is the development of new MRI techniques, or new combinations of established techniques, for distinguishing tumors from normal tissue or inflammation. This is an important clinical diagnostic problem when diagnosing or staging cancer. While conventional MRI can often detect tumors, it is often difficult to distinguish them from imflammation or edema. A secondary goal is relating MR images to tumor vascular patterns and tumor oxygenation. Tumor oxygenation is an important factor in determining the response to radiation therapy. These goals will be approached by combining the information obtained from images of protons, fluorine, and sodium. The proton images will be used for their anatomical detail. The fluorine images will be of fluorinated blood substitutes and will dilineate vascular anatomy and measure the vascular oxygen tension. The sodium images will be of endogenous sodium which in biological systems shows two components of T2 decay. Chemical shift reagents will be used to identify the intra and extracellular components. We will determine whether the short T2 component can be used to distinguish tumors from edema. The work will be done in a variety of animal tumors of known vascularity and radiosensitivity. If successful, the techniques can be transferred to human imaging and should lead to improved tumor diagnosis.