CHEMOPREVENTION OF LUNG CANCER--RETINOIDS/BETA-CAROTENE

这项化学预防试验测试了视黄醇和β- 胡萝卜素在预防肺癌两个相关的高风险 人口：（a）从基于保险的 （B）目前和以前的工人， 职业性石棉暴露 补偿和就业来源。 双盲 两组随机方案比较安慰剂与每日 30毫克β-胡萝卜素加25，000 IU视黄醇的组合。 我们 将从凯撒医疗机构招募符合条件的重度吸烟者 在波特兰，俄勒冈州大都市区的成员。 我们将 参与实施一个具有成本效益的、整合良好的、 多诊所战略，西雅图协调中心 用于项目管理和数据分析。 前3 在新的资助期（1988- 1991年）内， 根据多中心方案随机分配2200例受试者。 我们将提供所有必要的数据来评估应计利润， 协调，以及地理上分散的诊所地点的成本， 对全面的剩余需求进行最佳估计 入组和随访。 目前的假设和预测 表明全规模疗效试验将能够 检测到肺癌发病率的显著降低， 合并的高风险组，以及单独的任一亚组， 13，000名吸烟者和4，000名石棉接触者。

This chemoprevention trial tests the efficacy of retinol and beta- carotene in preventing lung cancer in two related high-risk populations: (a) heavy smokers recruited from insurance-based sources, and (b) current and former workers with heavy occupational asbestos exposure recruited from workers' compensation and employment-based sources. The double-blind two-arm randomized protocol compares placebos with a daily combination of 30 mg beta-carotene plus 25,000 IU retinol. We will recruit eligible heavy smokers from the Kaiser Permanente membership in the Portland, Oregon metropolitan area. We will participate in implementing a cost-effective, well-integrated, multi-clinic strategy, with the Seattle-based coordinating center for project management and data analysis. During the first 3 years of the new grant period (1988-91) we will recruit and enroll 2200 subjects randomized according to the multi-center protocol. We will provide all necessary data to evaluate accrual, coordination, and costs in geographically-dispersed clinic sites to generate best estimates of the remaining needs for the full-scale enrollment and follow-up. Current assumptions and projections indicate that the full-scale Efficacy Trial will be capable of detecting significant reductions in lung cancer incidence in the high-risk groups combined, and in either subgroups alone, with 13,000 smokers and 4,000 asbestos-exposed subjects.