权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

HEALTH AND OCCUPATIONAL EXPOSURE TO ANTI-CANCER DRUGS

健康和职业接触抗癌药物

基本信息

批准号：
2092704
负责人：
Barbara G. Valanis
金额：
$ 14.21万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-04-01 至 1995-03-31
项目状态：
已结题

项目摘要

The objectives of this study are to determine whether handling anti- neoplastic drugs or caring for patients receiving treatment with these drugs presents a risk to the health of staff, and to evaluate the relationship between work practices and various measures of exposure to these drugs. The specific aims are (1) to investigate whether specific work practices are associated with reproductive effects on health among nurses, pharmacists and nurses' aides, (2) to evaluate the relationship between work practices and exposure to antineoplastic drugs as measured by an industrial hygiene test and a urine mutagen test and (3) to investigate relationships among internal and external exposure measures and results on clinical laboratory tests which may reflect effects of exposure. The study is a competing continuation involving further data analysis of an existing dataset. Subjects are exposed nurses and pharmacists who handle antineoplastics, and nurses, aides caring for patients on treatment protocols at participating member facilities of the NSABP project of the NCI, including private physician's offices involved in NSABP clinical trials. Controls are unexposed pharmacists, nurses, and aides from these same facilities. Data was gathered in two phases: Phase I was a survey using a self-completion questionnaire covering demographic and control variables, exposure. history, and a health and reproductive history. Phase II collected, from a subsample of subjects in Phase I, updated exposure and health histories, data on other chemical exposures which could affect urine mutagenesis, an industrial hygiene measure of adriamycin exposure; blood and urine samples for clinical laboratory tests and urine mutagenesis, and an exposure log.

本研究的目的是确定是否处理抗- 肿瘤药物或护理接受这些治疗的患者药物对工作人员的健康构成风险，并评估工作实践与各种暴露措施之间的关系这些药物。具体目的是（1）调查是否有特定的工作实践与生殖对健康的影响有关，护士、药剂师和护士助理;（2）评估工作实践和暴露于毒品之间的关系，通过工业卫生试验和尿诱变剂试验，和（3），调查内部和外部暴露措施之间的关系和临床实验室检查结果，可能反映 exposure. 这项研究是一个竞争性的继续，涉及更多的数据分析现有的数据集。受试者是暴露的护士，处理抗菌塑料的药剂师，护士，参与成员设施的治疗方案的患者国家癌症研究所的NSABP项目，包括参与的私人医生诊所在NSABP临床试验中。对照组是未暴露的药剂师，护士，和助手都来自这些机构数据分两个阶段收集：第一阶段是使用自我完成问卷进行调查，人口统计学和控制变量，暴露。历史，健康，生殖史从受试者子样本中采集II期数据在第一阶段，更新接触和健康史，暴露可能影响尿液诱变，阿霉素暴露量测定;临床用血液和尿液样本实验室测试和尿液诱变，以及暴露日志。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ASSOCIATION OF ANTINEOPLASTIC DRUG HANDLING WITH ACUTE ADVERSE-EFFECTS IN PHARMACY PERSONNEL

DOI：
10.1093/ajhp/50.3.455
发表时间：
1993-03-01
期刊：
AMERICAN JOURNAL OF HOSPITAL PHARMACY
影响因子：
0
作者：
VALANIS, BG;VOLLMER, WM;GLASS, AG
通讯作者：
GLASS, AG

Occupational exposure to antineoplastic agents: self-reported miscarriages and stillbirths among nurses and pharmacists.

抗肿瘤药物的职业暴露：护士和药剂师自我报告的流产和死产。

DOI：
10.1097/00043764-199908000-00004
发表时间：
1999
期刊：
Journal of occupational and environmental medicine
影响因子：
3.2
作者：
Valanis,B;Vollmer,WM;Steele,P
通讯作者：
Steele,P

Antineoplastic drug handling protection after OSHA guidelines. Comparison by profession, handling activity, and work site.

遵循 OSHA 指南的抗肿瘤药物处理保护。

DOI：
10.1097/00043764-199202000-00014
发表时间：
1992
期刊：
Journal of occupational medicine. : official publication of the Industrial Medical Association
影响因子：
0
作者：
Valanis,B;Vollmer,WM;Labuhn,K;Glass,A;Corelle,C
通讯作者：
Corelle,C

Implementing a cancer-control study in a National Cancer Institute clinical trials network.

在国家癌症研究所临床试验网络中实施癌症控制研究。