Novel models to advance our understanding of mammalian development

该项目旨在增加对支持哺乳动物发育的细胞过程的理解。蛋白质磷酸化是一个由蛋白激酶和蛋白磷酸酶共同调控的动态过程。虽然激酶在细胞功能中的作用已经很好地定义，但蛋白磷酸酶的作用还没有很好地理解。利用一系列实验室模型，该项目旨在发现磷酸酶PP2A在细胞增殖、存活、分化和DNA损伤修复中的功能。预期的结果是提高对哺乳动物发育各个阶段的理解。这将为生物技术、化学和制药工业带来巨大的好处。

This project aims to add to the understanding of cellular processes underpinning mammalian development. Protein phosphorylation is a dynamic process regulated by both protein kinases and protein phosphatases. While the role of kinases in cellular functions are well defined, the roles of protein phosphatases are not well understood. Using a range of laboratory models this project aims to discover the function of the phosphatase PP2A, in cell proliferation, survival, differentiation and DNA damage repair. The anticipated outcome is an improved understanding of all stages of mammalian development. This will provide significant benefits in the biotechnology, chemical and pharmaceutical industries.