CHEMOPREVENTION OF LUNG CANCER--RETINOIDS/BETA-CAROTENE

这项化学预防试验测试了视黄醇和β-视黄醇的疗效。 胡萝卜素在预防肺癌相关高危人群中的作用 人口：(A)从保险公司招募的重度吸烟者 来源，以及(B)现任和前任工人 从工人招募的职业石棉暴露量 薪酬和以就业为基础的来源。双盲人 双臂随机方案比较安慰剂和每日一次 30毫克β-胡萝卜素和25,000国际单位视黄醇的组合。我们 将从Kaiser Permanente招募符合条件的重度吸烟者 俄勒冈州波特兰大都市区的会员资格。我们会 参与实施经济高效、集成良好的 多诊所战略，与西雅图的协调中心 用于项目管理和数据分析。在前3个月 在新的资助期内(1988-91)，我们将招募和注册 2200名受试者按多中心方案随机分组。 我们将提供所有必要的数据来评估应计项目， 地理位置分散的诊所站点的协调性和成本 生成对全面的剩余需求的最佳估计 招生和后续工作。当前的假设和预测 表明全面的疗效试验将能够 检测到肺癌发病率在 高危人群合并，且仅在任一亚组中， 13,000名吸烟者和4,000名接触石棉的受试者。

This chemoprevention trial tests the efficacy of retinol and beta- carotene in preventing lung cancer in two related high-risk populations: (a) heavy smokers recruited from insurance-based sources, and (b) current and former workers with heavy occupational asbestos exposure recruited from workers' compensation and employment-based sources. The double-blind two-arm randomized protocol compares placebos with a daily combination of 30 mg beta-carotene plus 25,000 IU retinol. We will recruit eligible heavy smokers from the Kaiser Permanente membership in the Portland, Oregon metropolitan area. We will participate in implementing a cost-effective, well-integrated, multi-clinic strategy, with the Seattle-based coordinating center for project management and data analysis. During the first 3 years of the new grant period (1988-91) we will recruit and enroll 2200 subjects randomized according to the multi-center protocol. We will provide all necessary data to evaluate accrual, coordination, and costs in geographically-dispersed clinic sites to generate best estimates of the remaining needs for the full-scale enrollment and follow-up. Current assumptions and projections indicate that the full-scale Efficacy Trial will be capable of detecting significant reductions in lung cancer incidence in the high-risk groups combined, and in either subgroups alone, with 13,000 smokers and 4,000 asbestos-exposed subjects.