PLASMA LIPIDS AND FAMILIAL BREAST CANCER

拟议研究的长期目标是确定以下因素 影响乳腺癌发病率，并利用这些信息在 研究预防这种疾病的方法。具体地说，它是 建议确定血浆脂质和脂蛋白水平是否 正如之前的研究表明的那样，这与乳腺癌的家族风险有关。 拟议研究的目的仅仅是确定一项 血脂浓度与家族性高血压的关系 乳腺癌的风险，目前还不能确定是否有这样的 联想起源于基因。据预测，高密度脂蛋白胆固醇将是 高脂血症家庭成员女性的甘油三酯升高和甘油三酯降低 与家庭成员中非女性相比患乳腺癌的风险 增加了患病的风险。 家庭将从广泛的家系中选出，这些家系已经 为克雷顿大学的乳腺癌患者编写的。这些 家谱将被用来识别两种类型的家系。其中一个是在 至少有2名一级亲属患上了乳腺癌(称为 家族性乳腺癌)和另一例乳腺癌发生在 至少3代只有1名女性(称为零星乳房 癌症)。家族性乳腺癌家庭将与家庭配对 根据确诊时的年龄判断是否患有散发性乳腺癌。 年乳腺癌病例的未受影响的一级女性亲属 这样确定的家庭将被要求参加一项研究，并 对人口统计、流行病学和营养数据进行测量 空腹采血，用于测量血浆脂质。 不同家庭配对的女性成员(零星和家族性) 然后将乳腺癌的发展风险与 确定是否存在家族风险之间存在关联的证据 乳腺癌和血脂水平的关系。其他变量的影响 然后将对发现的任何关联进行检查。这些变量 将包括体重营养摄入量、酒精摄入量、激素 使用和吸烟状态。

The long term goal of the proposed research is to identify factors that influence the incidence of breast cancer and to exploit this information in research into methods of preventing the disease. Specifically, it is proposed to determine whether plasma levels of lipids and lipoproteins are related, as previous work has suggested, to familial risk of breast cancer. The purpose of the proposed study is solely to determine whether a relationship exists between the concentration of plasma lipids and familial risk of breast cancer and not at this stage to determine whether any such association is genetic in origin. It is predicted that HDL-C will be elevated and TG depressed in women who are members of families at increased risk of breast cancer compared to female members of families who are not at increased risk of the disease. Families will be selected from the extensive pedigrees that have been compiled for patients with breast cancer at Creighton University. These pedigrees will be used to identify 2 types of families. One in which at least 2 first degree relatives have developed breast cancer (referred to as familial breast cancer) and another in which breast cancer has occurred in only 1 women in at least 3 generations (referred to as sporadic breast cancer). Families with familial breast cancer will be matched with families with sporadic breast cancer according to the age at diagnosis of the case. The unaffected first degree female relatives of the breast cancer cases in the families so identified will then be asked to participate in a study and measurement made of demographic, epidemiological, and nutritional data and fasting blood obtained for measurement of plasma lipids. Female members of pairs of families (sporadic and familial) at different risks for the development of breast cancer will then be compared to determine whether evidence exists of an association between familial risk of breast cancer and plasma lipid level. The influence of other variables on any association that is found will then be examined. These variables will include body weight nutritional intake, alcohol consumption, hormone use, and smoking status.