EPIDEMIOLOGY OF DRUG ABUSERS & SPONTANEOUS ABORTIONS

拟议的分析将加深我们对可能的 滥用某些药物对生殖的影响 对已知染色体异常的自然流产的观察 特色 母亲接触大麻，海洛因， 美沙酮、可卡因、地西泮和苯丙醇胺（PPA） 正常自然流产和染色体异常自然流产 各种类型的流产（例如，三体，X单体，三倍体）将是 评估。 此外，父亲使用大麻与 自然流产，根据流产体和母体染色体核型定义 使用大麻会导致胎儿宫内发育迟缓和早产 接受检查。 这些数据来自流行病学、细胞遗传学和病理学的综合研究。 自然流产的研究。 系统用药和药物使用 已经从连续12年的时间段中获得了历史， 一系列因自然流产而寻求医院护理的妇女（例）， 对照 在约2700名自然流产妇女的总数据中， 已知的核型和4600对照可用于拟议的 分析。 这些已经收集的数据提供了一个独特的机会， 就药物滥用与生殖的可能关系发表意见。

The proposed analyses will deepen our understanding of the possible reproductive effects of selected drugs subject to misuse by extending observations to spontaneous abortions of known chromosomal characteristics. The relations of maternal exposure to marijuana, heroin, methadone, cocaine, diazepam and phenylpropanolamine (PPA) to chromosomally normal spontaneous abortions and to chromosomally abnormal spontaneous abortions of various types (e.g. trisomy, monosomy X, triploidy) will be assessed. In addition, the relation of paternal marijuana use to spontaneous abortion, defined by karyotype of the abortus, and of maternal marijuana use to intrauterine growth retardation and preterm delivery will be examined. The data derive from a combined epidemiologic, cytogenetic and pathologic study of spontaneous abortions. Systematic medication and drug use histories have been obtained over a 12 year period from a consecutive series of women seeking hospital care for spontaneous abortion (cases) and controls. In total data from about 2700 women with spontaneous abortions of known karyotype and 4600 controls are available for the proposed analyses. These already collected data provide a unique opportunity to extend observations on the possible relations of drug abuse to reproduction.