MARIJUANA SMOKING TYPOGRAPHY AND DOSE REGULATION

我们将确定人们监管的范围和方式 大麻过程中吸收的四氢大麻酚(THC)和其他物质 抽烟。青少年和成年吸食大麻者之间的比较， 经常和不经常使用的人，男性和女性，那些也使用 烟草和非烟草使用者将演示这些技术、限制 以及吸食大麻时剂量调节的大小 威力。将应用已经开发的可靠的测量技术 大麻剂量学研究。吹气和吸气的模式， 包括通过流量计技术和吸入法测量的喷雾量 通过电感气体描记术测量的体积，将提供无创和 每支香烟是如何一口接一口地吸的精确描述。 心血管、自主神经和主观影响以及血浆THC， 11-羟基THC、11-Nor-9-羧基THC和羧基血红蛋白的措施将 允许确定吸烟模式之间的关系，从而 血液水平和影响。心得安诱导的β-肾上腺素能阻断和 由此导致的吸烟行为的变化将检验吸烟行为的重要性 剂量调节中的自主神经系统反馈。 吸烟者剂量控制的健康意义直到最近才被 在烟草研究中受到一些研究人员的赞赏。它可能是类似的 对吸食大麻的人来说很重要。几个学科，包括 精神药理学，心理生理学，呼吸生理学， 涉及药代动力学和行为医学。这些研究已经 直接影响公共健康，因为与任何药物一样，剂量很可能 既涉及严重后果，也涉及长期后果。人际关系 在大麻的效力和由此吸收的物质数量之间 很少有人研究过。只有对吸烟行为的不完全衡量才能 曾被用于大麻研究。详细考查 青少年吸烟者的大麻吸烟行为可能会加强预防 战略。

We will determine the extent and the means by which people regulate tetrahydrocannabinol (THC) and other substances absorbed during marijuana smoking. Comparisons between adolescent and adult marijuana smokers, frequent and infrequent users, males and females, those who also use tobacco and nontobacco users will demonstrate the techniques, the limits and the magnitude of dose regulation while smoking marijuana of various potency. Reliable measurement techniques already developed will be applied to the cannabis dosimetry research. Puffing and inhaling patterns, including puff volume measured by flow meter techniques and inhalation volume measured by inductance pneumography, will provide a noninvasive and precise protile of how each cigarette is smoked on a puff by puff basis. Cardiovascular, autonomic, and subjective effects and plasma THC, 11-hydroxy THC, 11-nor-9-carboxy THC and carboxyhemolobin measures will allow determination of relationships between smoking patterns, resulting blood levels and effects. Propranolol induced beta adrenergic blockade and resulting changes in smoking behavior will examine the importance of autonomic system feedback in dose regulation. The health significance of a smokers' dose control is only recently being appreciated by some researchers in tobacco studies. It may be of similar importance to marijuana smokers. Several disciplines, including psychopharmacology, psychophysiology, respiratory physiology, pharmacokinetics and behavioral medicine, are involved. The studies have direct public health implications since, as with any drug, dose is likely to be related to both acute and long term consequences. The relationships between marijuana potency and resulting amounts of material absorbed have been little studied. Only incomplete measures of smoking behavior have been previously used in marijuana research. The detailed examination of marijuana smoking behavior in adolescent smokers may enhance prevention strategies.