SINGLET OXYGEN AND LUNG PATHOGENESIS

单重态分子氧以三角态的形式，DeltaO2已经 被确认为潜在的大气氧化剂。尽管周围的环境水平 都没有被很好地建立起来，它的寿命足够长，足以发生反应 与大气污染物和/或如果吸入到达肺泡区 肺脏的。在大气中，它可以与烯烃和多环化合物反应。 芳香烃形成有毒的和可能具有致突变性的化合物 如果注射会对人体健康有害。也有可能是 单线态氧可以通过多种机制在原位形成，例如 臭氧与生物底物的反应。肺内单线态氧 是一种可以使肺部产生细微化学变化的物质 肺表面活性物质、肺泡巨噬细胞和肺上皮细胞 易患各种病理疾病。在这方面，它是 单线态氧很可能会攻击不饱和脂肪酸 肺泡磷脂通过“烯”形成过氧化氢的部分 反应。可能的氧化产物中有丙二酰基。 最近被报道具有致癌作用的乙醛 活动。此外，过氧化氢是一种已知的毒素，可以发挥其 对肺部的影响，导致炎症、水肿和出血。这个 肺内过氧化氢的形成及其作用机制 对肺组织的影响目前还没有报道。他们可能会 产生类脂环氧化物。这些物质可以起烷化剂的作用。 并可能最终导致突变或致癌。 据此，提出了确定单重态作用的研究方案 环境污染中的增量氧及其对环境的进一步影响 环境健康。

Singlet molecular oxygen in the form of the delta state, DeltaO2 has been identified as a potential atmospheric oxidant. Although the ambient levels of DeltaO2 are not well established it is sufficiently long lived to react with atmosphere pollutants and/or if inhaled to reach the alveolar region of the lung. In the atmosphere it can react with olefins and polycyclic aromatic hydrocarbons to form toxic and possibly mutagenic compounds which would be harmful to human health if injected. It is also possible that singlet oxygen may form in situ by a number of mechanisms, e.g., the reaction of ozone with biological substrates. In the lung singlet oxygen is an agent that can produce subtle chemical alterations of the pulmonary surfactant, alveolar macrophages and the pulmonary epithelium which can predispose to various pathological conditions. In this respect it is likely that singlet delta oxygen will attack the unsaturated fatty acid moieties of the alveolar phospholipids forming hydroperoxides via the "ene" reaction. Among the possible oxidation products to be expected is malonyl aldehyde which has recently been reported to exhibit carcinogenic activity. Also, the hydroperoxides are known toxins that exert their effects on the lungs causing inflammation, edema and hemorrhaging. The formation of hydroperoxides in the lung and the mechanism by which they act on the tissue of the lung are at the present time unreported. They may give rise to lipid epoxides. These substances can act aklylating agents and may be ultimately be responsible for mutagenesis or carcinogenesis. Accordingly research program is proposed to determine the role of singlet delta oxygen in environmental pollution and further its impact on environmental health.