COGNITIVE FUNCTIONING OF ABSTINENT COCAINE ABUSERS

1.计划对神经心理学测试进行纵向研究 一群可卡因滥用者的表现，他们已经禁欲了 八天，以确定功能障碍，通过比较其 与匹配的非药物对照组的性能。 这两 年龄（现在）[26至33]岁），将是非治疗社区 黑人科目谁曾在全国深入研究 围产期合作项目，从出生到7岁。 因此，全面的前物质使用数据将提供给 控制长期使用可卡因的影响。 此外，系统 这些科目的学校记录数据，从他们13岁到15岁 年龄（加州成就测试分数，等级和出勤记录 在9年级）将可从费城学校 区，作为额外的前物质使用控制。 2.两组住院的可卡因滥用者将在两个 在相同的神经心理学测试程序上的不同时间段， 上述社区非治疗组，并将比较他们的 与对照组进行比较。 其中一个住院组 将在禁欲8天和22天时进行评估，另一个将 在禁欲8天和35天时进行评估。 这些住院的可卡因 所有的人都已经使用可卡因至少三年了， 被DSM-III-R和SCID诊断为可卡因滥用者。 科帕卡巴纳将是 他们的主要毒品问题，他们只会使用酒精， 大麻或其他非法物质在有限的范围内（将 上面提到的社区团体）。 将确定是否发现任何功能缺陷， 与可卡因戒断时间有关。

1. A longitudinal study is planned of the neuropsychological test performance of a group of cocaine abusers, who have been abstinent for eight days, to determine impairment in functioning, by comparing their performance with that of a matched non-drug control group. These two groups (now) [26 to 33] years of age), will be non-treatment community black subjects who had been studied intensively in the National Collaborative Perinatal Project (NCPP), from birth to seven years of age. Thus, the comprehensive pre-substance use data will be available to control for the effects of long-term cocaine use. Also, systematic school record data on these subjects, from when they were 13 to 15 years of age (California Achievement Test Scores, grades and attendance records during the 9th grade) will be available from the Philadelphia School District, to utilize as additional pre-substance use controls. 2. Two groups of hospitalized cocaine abusers will be assessed at two different time periods on the same neuropsychological test procedures as the community non-treatment groups above, and will be compared on their performance with matched control groups. One of these inpatient groups will be assessed at 8 days and 22 days of abstinence, and the other will be assessed at 8 days and 35 days of abstinence. These inpatient cocaine groups will all have used cocaine for at least three years, and they will be diagnosed as cocaine abusers by DSM-III-R and SCID. Cocaine will be their primary drug problem, and they will only have used alcohol, marijuana or other illicit substances to a limited extent (as will the community groups referred to above). It will be determined whether any deficit in functioning that is found for cocaine abusers is related to the duration of abstinence for cocaine.