HLA AND TRANSPLANTATION

该项目的主要目的是继续研究同种异体移植物 问题. 影响移植存活的因素研究将利用 过去12年收集的广泛数据库和分析将 使用现场计算机设施完成。 需要审查的因素包括 HLA-DR组织相容性匹配，可能的增强抗体， 输血效应 将努力设计各种手段， 可以检测到由输血诱导的增强抗体。 血清 随后排斥移植物的患者将与那些 移植成功 抗免疫球蛋白抗体是 被假定为增强抗体的抗体。

The primary aim of this project will be continued study of the allograft problem. Studies of factors influencing transplant survival will utilize an extensive data base collected over the past 12 years and analyses will be done using an on-site computer facility. Factors to be examined include HLA-DR histocompatibility matching, possible enhancing antibodies, and the transfusion effect. Efforts will be made to devise means by which enhancing antibodies induced by transfusiuons can be detected. Sera from patients who subsequently reject grafts will be compared to those with successful grafts. Antimmunoglobulin antibodies are the principal antibodies postulated to be enhancing antibodies.