MECHANISM OF ACTION OF GROWTH HORMONE

这一建议旨在阐明增长的方式。 激素调节与能量代谢有关的代谢途径。 尽管它是脑下垂体激素中含量最丰富的，而且很明显 影响增长，其对反应的影响的本质 组织仍不清楚。尽管在生产方面取得的最新成就 合成生长激素有望缓解有限的短缺 它在治疗上的应用，对它在治疗中的作用认识不足 组织的发育及其新陈代谢的调节可能会受到限制 该药对患者的治疗效果。 未来。更好地了解这种激素在正常人群中的作用 个人可能会改善其他药物的管理，其中许多 这可能会影响许多代谢过程，这些过程是 受生长激素以及其他激素和代谢的调节 各种因素。 这项建议的具体目标是： 1.分离和鉴定位于细胞膜上的生长激素受体 脂肪组织细胞表面。 2.调查细胞内浓度是否有可能 钙和磷脂衍生的代谢中间产物可能起作用 作为第二个信使。 3.继续研究生长的几个代谢目标 荷尔蒙的作用以及它们之间的相互关系。

This proposal is directed towards elucidation of the means by which growth hormone regulates metabolic pathways related to energy metabolism. Although it is the most abundant of the pituitary hormones and clearly influences growth, the essential nature of its effects on responsive tissues remains unknown. Although recent achievements in the production of synthetic growth hormone promise to relieve the shortage which has limited its use therapeutically, the poor understanding of its role in the devlopment of tissues and in the regulation of their metabolism may limit the effectiveness with which it may be administered to patients in the future. A better understanding of the function of this hormone in normal individuals is likely to improve the administration of other drugs, many of which are likely to affect many of the metabolic processes which are regulated by growth hormone as well as by other hormonal and metabolic factors. The specific aims of this proposal are: 1. To isolate and characterize the growth hormone receptors located on the surface of adipose tissue cells. 2. To investigate the possibility that intracellular concentrations of calcium and of metabolic intermediates derived from phospholipids may act as a second messenger. 3. To continue investigations of several of the metabolic targets of growth hormone action and how they are related to one another.