HDHL-Biomarkers: CirculAting Bile Acids as biomarkers of metabolic health - Linking microbiotA, Diet and Health (CABALA_DIET&HEALTH)

胆汁酸（BA）通过TGR5和FXR调节哺乳动物的炎症、脂质、葡萄糖和能量代谢，并反过来受到肠道中饮食和微生物相互作用的调节。CABALA_DIET&HEALTH旨在建立循环BA谱作为健康的生物标志物，由饮食调节，反映代谢健康的变化。利用现有数据和新的机制研究，我们将在人类中提供直接证据，证明饮食：肠道微生物群相互作用调节血浆BA谱和调节宿主健康。我们的目标是确定血浆BA谱作为健康生物标志物，并建立BA信号的微生物群调节作为有效的益生菌，益生元和多酚功能食品的统一分子基础。

Bile acids (BA) through TGR5 and FXR regulate mammalian inflammation, lipid, glucose, and energy metabolism, and are in turn regulated by diet:microbe interactions in the gut. CABALA_DIET&HEALTH aims to establish circulating BA profiles as biomarkers of health, modulated by diet which reflect a change in metabolic health. Using existing data and new mechanistic studies we will provide direct evidence in humans that diet:gut microbiota interactions modulate plasma BA profiles and modulate host health. Our aim is to identify plasma BA profiles as health biomarkers and establish microbiota modulation of BA signalling as a unifying molecular basis for efficacious probiotic, prebiotic and polyphenol functional foods.