MICA: Reducing cardiovascular disease risk through replacement of saturated fat in milk and dairy products

MICA:通过替代牛奶和乳制品中的饱和脂肪来降低心血管疾病风险

基本信息

  • 批准号:
    MR/K020218/1
  • 负责人:
  • 金额:
    $ 99.88万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2013
  • 资助国家:
    英国
  • 起止时间:
    2013 至 无数据
  • 项目状态:
    已结题

项目摘要

Within the UK, Europe and North America heart disease is the major cause of ill health and death. Diet has an important impact on heart disease risk and studies have shown that good dietary habits at a young age and throughout the lifespan can reduce the excessive economic and social burden associated with heart disease, by helping to prevent or delay its development. The Department of Health has dietary recommendations to reduce disease risk, principally a reduction in total saturated fat (hard fats found in processed and animal derived foods) intake. However currently, the UK population considerably exceeds this saturated fat target. Milk and milk products are one of the largest sources of dietary saturated fat, contributing about 30% of the total with cheese and butter contributing most. A common strategy to reduce saturated fat intake is to advise reduction or removal of milk and dairy products from the diet. However milk is an important food providing essential nutrients such as calcium, B vitamins and iodine, particularly important for children, young women and older adults and their reduction may lead to detrimental effects on nutritional status and health. In addition, evidence suggests that there are likely to be benefits of increased dairy food consumption such as milk in terms of lower blood pressure, reduced incidence of heart disease and some cancers, although there is limited evidence for cheese and butter. Thus simply reducing milk intake to reduce saturated fat consumption is likely to be counterproductive. Studies with humans where blood cholesterol has been measured suggest that replacing a proportion of the saturated fat in the diet with mono or polyunsaturated fats (typically found in vegetable oils) does improve their cardiovascular health value. There is now good evidence that changing the diet of the dairy cows can provide a sustainable means of producing milk with reduced saturates and increased monounsaturates, although because of the complex nature of dairy foods it cannot be simply assumed that such modified foods will reduce the risk of heart disease. Such changes to the diet of the dairy cow may also have environmental benefits as they are likely to reduce the amount of methane (a potent greenhouse gas) produced by the cow thus reducing the carbon footprint associated with milk production. This project will examine the health benefits of such modified milk and dairy products in controlled human and laboratory studies using traditional and new methods of assessing heart disease risk. In the first part of the project, dairy products with reduced saturated fats and increased monounsaturated fats will be produced by changing the cow's diet. A detailed human study will then be undertaken to assess the long and short-term effects of including these dairy products in the diet and individual meals. New, more valuable methods of assessing changes in the risk of heart disease will be included as these are thought to be more predictive than the traditional approaches relying on blood cholesterol. In the third part of this project we will complement the human studies by determining in the laboratory how the modified milk and commercial dairy products influence the health of human blood vessels, such as those found in the heart. Any benefits arising from this work will inform public health policy on optimum dietary strategies to prevent or delay the onset of heart disease.
在英国,欧洲和北美,心脏病是健康不良和死亡的主要原因。饮食对心脏病风险有重要影响,研究表明,年轻时和整个生命周期的良好饮食习惯可以通过帮助预防或延迟心脏病的发展来减少与心脏病相关的过度经济和社会负担。卫生部有减少疾病风险的饮食建议,主要是减少饱和脂肪(加工和动物源性食品中的硬脂肪)的摄入量。然而,目前,英国人口大大超过了这一饱和脂肪目标。牛奶和奶制品是膳食饱和脂肪的最大来源之一,约占总量的30%,其中奶酪和黄油的贡献最大。减少饱和脂肪摄入的一个常见策略是建议减少或从饮食中去除牛奶和乳制品。然而,牛奶是提供钙、B族维生素和碘等基本营养素的重要食物,对儿童、青年妇女和老年人尤其重要,牛奶的减少可能会对营养状况和健康产生有害影响。此外,有证据表明,增加奶制品消费量可能会带来好处,例如牛奶在降低血压,降低心脏病和某些癌症的发病率方面,尽管奶酪和黄油的证据有限。因此,简单地减少牛奶摄入量以减少饱和脂肪的消耗可能会适得其反。对人类进行的血液胆固醇测量研究表明,用单不饱和脂肪或多不饱和脂肪(通常存在于植物油中)取代饮食中一定比例的饱和脂肪确实可以改善心血管健康价值。现在有很好的证据表明,改变奶牛的饮食可以提供一种可持续的方法,生产出饱和度降低、单不饱和度增加的牛奶,尽管由于乳制品的复杂性,不能简单地假设这种改性食品会降低心脏病的风险。奶牛饮食的这种变化也可能具有环境效益,因为它们可能减少奶牛产生的甲烷(一种强效温室气体)的量,从而减少与牛奶生产相关的碳足迹。该项目将使用传统和新的评估心脏病风险的方法,在受控的人体和实验室研究中检查这种改性奶和奶制品的健康益处。在该项目的第一部分,将通过改变奶牛的饮食来生产减少饱和脂肪和增加单不饱和脂肪的乳制品。然后将进行一项详细的人体研究,以评估将这些乳制品纳入饮食和个人膳食的长期和短期影响。评估心脏病风险变化的新的、更有价值的方法将被包括在内,因为这些方法被认为比依赖于血液胆固醇的传统方法更具预测性。在本项目的第三部分,我们将通过在实验室中确定改性牛奶和商业乳制品如何影响人体血管的健康来补充人体研究,例如在心脏中发现的血管。这项工作所带来的任何好处都将为公共卫生政策提供关于预防或延迟心脏病发作的最佳饮食策略的信息。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Food chain approach to lowering the saturated fat of milk and dairy products
  • DOI:
    10.1111/1471-0307.12564
  • 发表时间:
    2019-02-01
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Kliem, Kirsty E.;Humphries, David J.;Lovegrove, Julie A.
  • 通讯作者:
    Lovegrove, Julie A.
Bioaccessibility and Digestibility of Lipids from Food
食物中脂质的生物可及性和消化率
  • DOI:
    10.1007/978-3-030-56909-9_6
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Givens D
  • 通讯作者:
    Givens D
Dairy products: good or bad for cardiometabolic disease?
乳制品:对心脏代谢疾病有益还是有害?
Technological Quality of Saturated Fat-Reduced Milk
饱和脱脂奶的技术品质
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fagan CC
  • 通讯作者:
    Fagan CC
Special issue: Lipids and their manipulation in animal-derived foods
特刊:动物源性食品中的脂质及其操纵
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Julie Lovegrove其他文献

OR19-06-23 Modelled Replacement of Meats by Dairy in Relation to Incident Cardiovascular Disease: European Investigation Into Cancer and Nutrition (EPIC)-Norfolk Study
  • DOI:
    10.1016/j.cdnut.2023.100614
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Yakima Vogtschmidt;Sabita Soedamah-Muthu;David Givens;Julie Lovegrove
  • 通讯作者:
    Julie Lovegrove
P02-040-23 The Acute Effects of Meals Rich in Saturated or Unsaturated Fatty Acids on Postprandial Lipaemia and Vascular Function in Healthy Sri Lankan Men (Coco Heart Sri Lankan Study)
  • DOI:
    10.1016/j.cdnut.2023.100271
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Kumari Rathnayake;Dilki Perera;Ananda Chandrasekara;Kim Jackson;Julie Lovegrove
  • 通讯作者:
    Julie Lovegrove
The Impact of Different Sources of Dietary Nitrate on Blood Pressure and Other Risk Factors for Cardiovascular Diseases in a Representative UK Population
  • DOI:
    10.1093/cdn/nzab044_003
  • 发表时间:
    2021-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Hayat Alzahrani;Kim Jackson;Ditte Hobbs;Julie Lovegrove
  • 通讯作者:
    Julie Lovegrove
Utilising the glycaemic index: An investigation of glycaemic response and cognition
  • DOI:
    10.1016/j.appet.2018.05.192
  • 发表时间:
    2018-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Matthew Grout;Daniel Lamport;Julie Lovegrove
  • 通讯作者:
    Julie Lovegrove
P11-048-23 Vitamin D Deficiency Is Associated With Less Favourable Body Fat Content and Distribution in Healthy Adults-Findings From the Cross-Sectional BODYCON Study
  • DOI:
    10.1016/j.cdnut.2023.101845
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Ezgi Ozen;Rada Mihaylova;Julie Lovegrove;Kim Jackson
  • 通讯作者:
    Kim Jackson

Julie Lovegrove的其他文献

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{{ truncateString('Julie Lovegrove', 18)}}的其他基金

'Raising the Pulse' (RtP): Systems analysis of the environmental, nutritional and health benefits of pulse-enhanced foods
“提高脉搏”(RtP):对脉搏强化食品的环境、营养和健康益处进行系统分析
  • 批准号:
    BB/W017946/1
  • 财政年份:
    2022
  • 资助金额:
    $ 99.88万
  • 项目类别:
    Research Grant
Mechanisms to Explain Variation in Serum Low Density Lipoprotein Cholesterol Response to Dietary Saturated Fat
解释血清低密度脂蛋白胆固醇对膳食饱和脂肪反应变化的机制
  • 批准号:
    BB/P009891/1
  • 财政年份:
    2017
  • 资助金额:
    $ 99.88万
  • 项目类别:
    Research Grant
HDHL-Biomarkers: CirculAting Bile Acids as biomarkers of metabolic health - Linking microbiotA, Diet and Health (CABALA_DIET&HEALTH)
HDHL-生物标记物:循环胆汁酸作为代谢健康的生物标记物 - 连接微生物 A、饮食和健康 (CABALA_DIET
  • 批准号:
    BB/P028209/1
  • 财政年份:
    2017
  • 资助金额:
    $ 99.88万
  • 项目类别:
    Research Grant
HDHL Biomarkers: Fatty Acid Metabolism - Interlinking Diet with Cardiometabolic Health (FAME)
HDHL 生物标志物:脂肪酸代谢 - 将饮食与心脏代谢健康联系起来 (FAME)
  • 批准号:
    BB/P028217/1
  • 财政年份:
    2017
  • 资助金额:
    $ 99.88万
  • 项目类别:
    Research Grant

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