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PERIPHERAL AND CENTRAL SATIETY ACTIONS OF BOMBESIN

PERIPHERAL AND CENTRAL SATIETY ACTIONS OF BOMBESIN
铃蟾肽的外周和中枢饱腹感作用
批准号：
3231645
负责人：
JAMES P GIBBS
金额：
$7.56万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
项目状态：
已结题
起止时间：
1983-12-01 至 1988-06-30
来源：
https://reporter.nih.gov/project-details/3231645
关键词：
anorexic agent appetite regulatory center behavior test cerebral ventricles eating experimental brain lesion gastrointestinal hormones hormone regulation /control mechanism hypothalamus nutrition related tag satiations stomach sympathectomy taste vagotomy

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中文摘要
翻译
这项建议有三个主要目的：
英文摘要
This proposal has three major purposes: First, to determine the site of action and afferent pathway for the satiety action of exogenous bombesin administered perpherally in the rat; Seconds, to test the hypothesis that the satiating effect of food in the stomach is mediated, at least in part, by bombesin released from the stomach in the rat; Third, to analyze the neural and/or endocrine mechanisms of the satiety effect of lateral hypothalamic injections of bombesin in the rat. The theme is to continue the analysis of the role of preabsorptive mechanisms (especially peptide functions) in the elicitation of postprandial satiety. The central goal is to determine the peripheral mechanisms controlling meal size. This knowledge should present opportunities to develop physiologically-based treatments for obesity and for bulimia.
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