INFLUENCE OF HEREDITY ON MEAL PATTERNS IN HUMANS

最近的证据有力地表明，成年人的体重 人类很大程度上受到遗传的影响(Bouchard et.艾尔， 1985年；1986年；布雷；1981年；Stunkard et.1966a；1986b)。自.以来 体重主要是通过进食产生和维持的， 影响体重的基因可能通过影响食物而起作用。 摄入量，具体地说，是指用餐的频率、成分或大小。 然而，目前还没有系统的遗传研究。 对人类饮食模式的影响。拟议的研究 会调查饮食行为是由基因决定的 通过研究和比较中国人的饮食模式确定的 同卵(MZ)和异卵(DZ)双胞胎。MZ和DZ双胞胎将 被要求记下他们吃的或喝的每一样东西 连续七天的用餐时间 句号。然后这些记录将以编码的形式输入计算机 记录的营养成分分析表格 一顿饭。整体营养素的异同 摄入量和进食的微观结构，包括膳食 构图，两餐之间的间隔，用餐模式 相关性和进食的昼夜分布将是 分别为MZ和DZ双胞胎确定。可继承性 这些因素的差异将根据差异进行估计 在MZ和DZ对的孪生内关联之间。这个 拟议的研究应该为遗传如何影响提供洞察力 人类的饮食模式，进而编码和维持身体 重量。这可能暗示了生理过程的本质。 是受基因影响的，并提出了干预方法 预防或治疗异常体重或饮食行为。

Recent evidence has strongly suggested that the adult body weight of humans is greatly influenced by heredity (Bouchard et. al., 1985; 1986; Bray; 1981; Stunkard et. al., 1986a; 1986b). Since body weight is principally produced and maintained by eating, the genes that influence body weight probably act by affecting food intake, specifically, the frequency, composition, or size of meals. There have been, however, no systematic studies of hereditary influences on the meal patterns of humans. The proposed research will investigate that aspect of eating behavior is genetically determined by studying and comparing the meal patterns of monozygotic (MZ) and dizygotic (DZ) twins. MZ and DZ twins will be asked to enter into a diary everything they either eat or drink and the time of the meals throughout a consecutive seven day period. The records will then be entered into a computer in coded form for analysis of the nutrient composition of the recorded meals. The similarities and differences between overall nutrient intakes and the microstructure of eating including the meal compositions, the intervals between meals, the meal pattern correlations, and the circadian distribution of eating will be determined separately for the MZ and DZ twins. The heritabilities of these factors will then be estimated based upon the difference between the intra-twin correlations for the MZ and DZ pairs. The proposed study should provide insights into how heredity influences the meal patterns of humans and in turn encodes and maintains body weight. This may suggest the nature of the physiological processes that are genetically influenced and suggest methods of intervention to prevent or treat abnormal body weight or eating behavior.