PROLACTIN REGULATION OF PROSTATE CITRATE PRODUCTION

我们的主要目标是通过以下方式阐明和理解这一机制 前列腺会发挥其独特的蓄积功能 分泌出超高水平的柠檬酸。特别的 重要的是阐明荷尔蒙在调节 前列腺素柠檬酸盐的生产。在人类中，前列腺癌构成 人类最常见的肿瘤疾病。良性前列腺 肥大和前列腺癌的特点是 生产柠檬酸盐的能力发生了变化。这些研究将导致 到最终了解正常前列腺的转变 细胞转化为肿瘤细胞，并可能提供一种合理的方法 激素相关药物在这些肿瘤的治疗中的应用。 本研究的重点是催乳素在调节 大鼠前列腺外侧分泌柠檬酸。侧方前列腺 与人类前列腺的侧叶同源。这些研究 将阐明催乳素对柠檬酸合成和柠檬酸的影响 氧化，以及催乳素调节柠檬酸的机制 制作。该计划将阐明 前列腺中的催乳素-锌-柠檬酸氧化。研究还将 确定催乳素调节基因作用的机制 与柠檬酸合成有关。与猪的比较研究 将进行前列腺检查，以提供确凿的证据 这些关系很可能适用于人类前列腺。

Our broad objectives are to elucidate and to understand the mechanism by which the prostate gland performs the unique function of accumulating and secreting extraordinarily high levels of citric acid. Of particular importance is elucidation of the role of hormones in the regulation of prostate citrate production. In humans, prostatic neoplasms constitute the most prevalent neoplastic disease in man. Benign prostatic hypertrophy and prostatic carcinoma are characterized by major alterations in the ability to produce citrate. These studies will lead to the eventual understanding of the transformation of normal prostate cells to neoplastic cells and might provide a rational approach to the use of hormonal-related agents in the management of these neoplasms. This project focuses on the role of prolactin in the regulation of citrate production by lateral prostate of the rat. The lateral prostate is homologous to the lateral lobe of the human prostate. The studies will elucidate the effect of prolactin on citrate synthesis and citrate oxidation, and the mechanisms by which prolactin regulates citrate production. The program will elucidate the interaction among prolactin-zinc-citrate oxidation in prostate. Studies will also determine the mechanism by which prolactin regulates gene action associated with citrate synthesis. A comparative study with pig prostate will be conducted which will provide corroborating evidence that these relationships are likely applicable to human prostate.