CLINICAL TRIALS ON HUMAN ISLET TRANSPLANTATION

描述：（改编自申请人的摘要）第一个具体 本申请的目的是确定有多少胰岛素依赖型糖尿病患者 糖尿病患者可以通过胰岛移植实现胰岛素非依赖性， 以及他们的移植能持续多久。 第一 研究是移植7天，24 ℃培养和冷冻保存 胰岛移植到已建立肾移植的I型患者中， MALG和基础免疫抑制。 第二项研究是移植7 每天，24摄氏度培养和冷冻保存的胰岛进入患者体内， 他们的肾移植 有了这些信息，下一步 将是确定免疫改变技术的能力， 长期免疫抑制。 第二特定 目的是将培养7天、冷冻保存的胰岛移植到I型 将接受胰岛治疗的进入肾衰竭的患者 培养和冷冻保存，多个供体，紫外线疗法，或 特异性抗II类抗体。 成功 这些研究的完成将决定 胰岛移植以达到其远期目的。

DESCRIPTION: (Adapted from the applicant's abstract) The first specific aim of this application is to determine how many insulin dependent diabetes mellitus patients can achieve insulin independence by islet transplants, and how long their grafts will last, in two groups of patients. The first study is to transplant 7 day, 24 degrees C cultured and cryopreserved islets into Type I patients with established kidney transplants with 7 days of MALG and basal immunosuppression. The second study is to transplant 7 day, 24 degrees C cultured and cryopreserved islets into patients getting their kidney transplant. With this information obtained, the next step will be to determine the ability of immunoalteration techniques to permit transplantation without long term immunosuppression. The second specific aim is to transplant 7 day cultured, cryopreserved islets into Type I patients entering renal failure who will have their islets treated with either culture and cryopreservation, multiple donors, UV light therapy, or specific anti-class II antibodies prior to transplantation. The successful completion of these studies will determine the practical feasibility of islet transplantation to achieve its long term objective.