Orchestrating cellular processes by engineering silicon nanowire architectures

该项目旨在通过创建低成本、易于实施、可编程和可控的硅微阵列介导的转染技术来改善基因转运，并展示生物活性有效载荷的高通量平行运输。成功将使纳米生物界面的设计和制造具有严格控制的几何形状和结构，以前所未有的效率和可预测性协调特定的细胞过程，如细胞重编程，粘附，形态和分化。这一进展可能会导致基础细胞研究的突破，并更好地了解细胞的行为，功能和命运。

This project aims to improve gene transport by creating low-cost, easily implemented, programmable and controllable silicon nanowire-mediated transfection technology, and to demonstrate high-throughput, parallel trafficking of bioactive payloads. Success would enable the design and fabrication of nano–bio interfaces with closely controlled geometry and architecture, to orchestrate specific cellular processes such as cellular reprogramming, adhesion, morphology, and differentiation with unprecedented efficiency and predictability. The advance could lead to breakthroughs in fundamental cellular studies, and better understanding of cell behaviour, function and fate.