Expanding the organometallic toolbox for constructing heterocycles

本项目旨在设计和合成立体特异的环状分子。这对化学家来说是一个问题，特别是当生物活性和药物相关性取决于复杂的立体化学和替代模式时。该团队将以他们发现的级联反应为基础，合成具有高度立体特异性的吲哚衍生物。他们将瞄准试剂和反应途径，以产生难以获得的杂环分子。他们将合成并表征同双金属和异双金属配合物，以开发与药物发现相关的环状分子和支架。新的分子和反应途径将与生物和药物化学以及药物发现计划相关。

This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules which are difficult to access. They will synthesise and characterise homo- and hetero-bimetallic complexes to develop cyclic molecules and scaffolds relevant in drug discovery. New molecules and reaction pathways will be relevant for biological and medicinal chemistry, and drug discovery programmes.