NEURAL EFFECTS OF LOW-LEVEL MICROWAVES

我们建议进行实验，继续研究 低强度微波辐射对大鼠神经功能的影响 大鼠 在以前的研究中，我们发现急性暴露于低- 水平微波影响钠依赖性高亲和力胆碱 摄取，神经组织中胆碱能活性的量度， 老鼠大脑的不同区域。 因为脑内的胆碱能系统 大脑发挥着重要的功能，我们将利用这种效应作为 因变量来研究（不同的 辐照参数：功率密度、持续时间、脉冲与 连续波辐射，以及圆偏振与平面偏振 波 微波引起的变化的功能后果 大脑中的胆碱能活动将通过研究 径向臂迷宫性能，短期空间的测量 记忆 通过治疗可能逆转学习缺陷 将对麻醉剂拮抗剂进行研究。 长期变化 将研究重复暴露后神经功能的变化 通过测量毒蕈碱胆碱能受体的性质， 大脑的不同区域。 其他参与 微波对中枢神经系统影响中的神经递质 胆碱能活性将通过用以下药物治疗动物来研究： 各种递质拮抗剂暴露前。 我们的研究数据还表明，一些神经系统疾病 低水平微波暴露的影响是由内源性的 阿片类药物 我们提出了一系列的实验来测量 三种内源性阿片类药物：β-内啡肽，甲硫氨酸， 脑啡肽和亮氨酸脑啡肽在大脑的不同区域 在急性或反复暴露于微波之后。 希望这项拟议研究的结果将进一步 我们对神经化学机制的理解， 低强度微波辐射对神经系统的影响 这些影响的后果。

We propose experiments to continue our studies on the effects of low-level microwave irradiation on neurological functions in the rat. In previous research, we found that acute exposure to low- level microwaves affected sodium-dependent high-affinity choline uptake, a measure of cholinergic activity in neural tissue, in various regions of the rat brain. Since cholinergic systems in the brain serve important functions, we will use this effect as the dependent variable to study the (interaction effects of different parameters of irradiation: power density, duration, pulsed versus continuous-wave irradiation, and circularly versus plane-polarized waves. Functional consequence of microwave-induced changes in cholinergic activity in the brain will be investigated by studying radial-arm maze performance, a measure of short-term spatial memory. Possible reversal of the learning deficit by treatment with narcotic antagonists will be investigated. Long-term changes in neural functions after repeated exposure will be investigated by measurements of muscarinic cholinergic receptor properties in different regions of the brain. Involvements of other neurotransmitters in the effects of microwaves on central cholinergic activity will be studied by treating animals with various transmitter antagonists before exposure. Data from our research also indicate that some of the neurological effects of low-level microwave exposure are mediated by endogenous opioids. We propose a series of experiments to measure the levels of three types of endogenous opioids: beta-endorphin, met- enkephalin, and leu-enkephalin, in different regions of the brain after acute or repeated exposure to microwaves. It is hoped that results from this proposed research will further our understanding of the neurochemical mechanism mediating the neurological effects of low-level microwave irradiation and the behavioral consequence of these effects.