RELATIONSHIP OF MAMMALIAN CONES TO PIGMENT EPITHELIUM

在过去的几年里，人们的兴趣集中在 其中脊椎动物杆和色素上皮（PE）相互作用，特别是与 关于外段盘的组装、脱落和消化。 然而，在这方面， 哺乳动物视锥细胞和PE之间的解剖学关系，以及它们的 相互作用，仍然知之甚少。 在这个研究项目中， 集中在两个方面：第一，建立正常的 哺乳动物视锥细胞外节（COS）和 第二，在描述发生的变化时， 当正常的细胞间关系被实验性地改变时， 被打乱了 正在进行的项目包括：（1）正常关系研究 灵长类视网膜中央凹和周边锥之间的关系;（2）研究 球果花盘脱落的节律性周期及其与光照的关系; 实验性视网膜脱离后超微结构的变化 在猫和恒河猴中的分离和随后的手术再附着。

Within the last several years much interest has been focused upon the ways in which vertebrate rods and the pigment epithelium (PE) interact, especially with regard to the assembly, shedding and digestion of outer segment discs. However, the anatomical relationship between mammalian cones and the PE, and their interactions, remain poorly understood. In this research project our efforts are concenrated in two general areas: first, in establishing the normal ultrastructural relationship between mammalian cone outer segments (COS's) and the PE by electron microscopy; and second, in describing the changes that occur when that normal intercellular relationship is experimentally altered or disrupted. Ongoing projects include: (1) a study of the normal relationship between foveal and peripheral cones in the primate retina; (2) a study of the rhythmic cycle of disc shedding in cones and its relationship to light; (3) an examination of the ultrastructural changes that occur after experimental retinal detachment and following surgical reattachment in cats and rhesus monkeys.