PREDICTIVE AND DIAGNOSTIC SCREENING TEST FOR GLAUCOMA

拍摄神经纤维层并进行分析的新技术 阈值视野检查已被证明具有潜在的敏感性和特异性。 早期到轻度青光眼视神经损害。在第二阶段 这项纵向前瞻性研究超过1600只眼 高血压，250例早期青光眼视野丧失，另有 200-400名正常对照将继续接受年度复查 包括蒙面、详细的手动自动动态和静态视野检查 阈值视野检查、临床评估、彩色立体摄影 视神经头和神经纤维层的无红照相 再加四年。 分析将确定NFL的敏感性和特异性 单独和/或与其他目视、系统和/或联合评估 人口统计因素，以及哪些阈值视野检查可以识别 有青光眼神经损害风险的个人(通过手动视野检查或 杯盘参数的变化，现有的“黄金标准”)每年 在发生这种损失之前的间隔时间。此外，地球的自然历史 这些眼睛的高眼压和相关变化将是 已经成立了。 这一发现可能导致新的青光眼手术定义用于诊断 和筛查目的，允许有效和高效的干预 在疾病过程的早期。

New techniques for photographing the nerve fiber layer and analyzing threshold perimetry have proved potentially sensitive and specific indices of early to mild glaucomatous optic nerve damage. During the second phase of this longitudinal prospective study over 1600 eyes with ocular hypertension, 250 with early glaucomatous field loss and an additional 200-400 normal controls will continue to undergo annual re-examination including masked, detailed manual kinetic and static perimetry, automated threshold perimetry, clinical assessment, color stereoscopic photography of the optic nerve head and red-free photography of the nerve fiber layer for an additional four years. Analysis will determine the sensitivity and specificity with which NFL assessment alone and, or in combination with other ocular, systemic and demographic factors, and with which threshold perimetry can identify individuals at risk of glaucomatous nerve damage (by manual perimetry or changes in cup-disc parameters, the existing "gold standards") at annual intervals before such loss occurs. In addition, the natural history of ocular hypertension and correlative changes in these eyes will be established. Findings may result in new operative definitions of glaucoma for diagnostic and screening purposes, permitting effective and efficient intervention earlier in the disease process.