OSCILLATORY POTENTIALS IN THE VISUAL SYSTEM

在之前的资助期，我已经成功实现了刺激 和记录条件，允许重复和可靠的 记录光诱发的高频小波（“振荡的 电位”），其从人的枕骨头皮获得。 该项目的具体目标是进一步了解 光诱发电生理的特点和起源 人类视觉系统的活动，并对这些应用 视觉系统异常和疾病的诊断措施。 的 为实现这些目标，提出了以下计划：第一阶段：调查 新生儿和婴儿VEP小波的发展。 列入 第一阶段将比较枕叶VEP的发育顺序 小波与慢波;小波与慢波函数的分析 波幅和内隐时间与刺激闪光强度的关系; 并分析了从皮层下到 发育中的婴儿的皮层视觉机制。 第二阶段： 研究记录的子波的特性和关系 眼睛（ERG）和头皮（VEP）。 第二阶段将包括 确定各种VEP小波之间的特定关系 和时间先行视网膜电图（ERG）小波; 研究不同电参考点对 头皮VEP小波分布; 空间频率调谐反映在小波的振幅和慢 波 第三阶段：研究VEP小波用于 视觉系统异常和疾病的诊断。 纳入III期 将是正常受试者VEP小波的眼间比较; 传入视神经中VEP小波变化的测定 传输缺陷;以及确定VEP小波的变化 糖尿病性视网膜病变 将记录ERG和VEP信号并计算机处理 分析，使用新开发的数字滤波技术。 光 刺激将被仔细校准和控制。 高的记录 频率VEP小波似乎代表了显着的优势， 传统的枕骨慢波（低频）记录 头皮，其中主要是相对更高的测量精度 最高峰。

In the previously funded period, I have succeeded in achieving stimulation and recording conditions which allow for the repeated and reliable recording of light evoked high frequency wavelets ("oscillatory potentials"), which are obtained from the occipital scalp in man. The specific aims of this project are directed toward further understanding of the characteristics and origins of light evoked electrophysiological activity of the human visual system, and toward the application of these measures to the diagnosis of visual system anomalies and disease. The following plan is proposed to achieve these aims: Phase I: Investigation of the development of VEP wavelets in newborns and infants. Included in Phase I will be a comparison of the developmental sequence of occipital VEP wavelets and slow waves; an analysis of the functions of wavelet and slow wave amplitude and implicit time as related to stimulus flash intensity; and an analysis in terms of the possible progression from subcortical to cortical visual mechanisms in the developing infant. Phase II: Investigation of specific properties and relationships of wavelets recorded at the eye (ERG) and at the scalp (VEP). Included in Phase II will be the determination of specific relationships between the various VEP wavelets and the temporally preceding electroretinogram (ERG) wavelets; investigation of the effects of different electrical reference sites upon the scalp distribution of VEP wavelets; investigation of the differences in spatial frequency tuning as reflected in the amplitude of wavelets and slow waves. Phase III: Investigation of the use of VEP wavelets for the diagnosis of visual system anomalies and disease. Included in Phase III will be inter-ocular comparisons of VEP wavelets in normal subjects; the determination of the changes in VEP wavelets in afferent optic nerve transmission deficits; and the determination of the changes in VEP wavelets in diabetic retinopathy. ERG and VEP signals will be recorded and computer analyzed, using newly-developed digital filtering techniques. Light stimuli will be carefully calibrated and controlled. The recording of high frequency VEP wavelets appears to represent significant advantages over the traditional recording of slower (lower frequency) waves from occipital scalp, chief among which is the relatively greater precision of measurement of peak latencies.