OCULAR PHARMACOKINETICS OF FLUORESCENT DRUG ANALOGUES

一系列荧光染料在兔眼内的动力学研究 将建立和相关的物理化学性质。 是 这将有助于设计治疗药物， 眼睛中所需的动力学特性。 动力学将在 眼内细胞屏障的渗透性术语， 在组织中扩散和结合。 将特别注意 晶体透镜对动力学的影响。 该染料是 研究将包括荧光酮，罗丹明，恶嗪，碳菁， 部花青和芘。 分子量，分配系数， 将建立离子电荷和pK，以及它们之间的相关性 性质和它们在眼睛中的渗透性等将被寻找。

The intraocular kinetics of a range of fluorescent dyes in the rabbit eye will be established and related to their physicochemical properties. It is intended that this will aid in the design of therapeutic drugs having desired kinetic properties in the eye. The kinetics will be analyzed in terms of the permeabilities of the intraocular cellular barriers and diffusion in and binding by the tissues. Particular attention will be paid to the influence of the crystalline lens on kinetics. The dyes to be investigated will include fluorones, rhodamines, oxazines, carbocyanines, merocyanines and pyrenes. Their molecular weight, partition coefficient, ionic charge and pK will be established, and correlations between these properties and their permeabilities, etc. in the eye will be looked for.