OSCILLATORY POTENTIALS IN THE VISUAL SYSTEM

在之前的资助期间，我成功地实现了刺激 以及允许重复和可靠的记录条件 记录光诱发的高频子波(“振荡” 电位“)，取自人的枕部头皮。 本项目的具体目标是为了进一步了解 光诱发电生理的特点及起源 人类视觉系统的活动，以及这些技术的应用 视觉系统异常和疾病的诊断措施。这个 为实现这些目标提出了以下计划：第一阶段：调查 新生儿和婴儿的VEP子波发育的研究。包括在 第一阶段是枕部VEP发育顺序的比较 小波与慢波；小波与慢波的函数分析 波幅和隐含时间与刺激闪光强度相关； 以及从皮质下到皮下的可能进展的分析 发育中婴儿的皮质视觉机制。第二阶段： 记录的子波的特殊性质和关系的研究 在眼睛(ERG)和头皮(VEP)。第二阶段将包括 确定不同VEP子波之间的特定关系 时间超前视网膜电信号(ERG)小波； 不同电学参照点对电信号的影响 头皮VEP子波分布的研究 空间频率调谐反映在子波的幅值和慢度上 海浪。第三阶段：研究VEP小波在脑电地形图中的应用 诊断视觉系统异常和疾病。包括在第三阶段 将是对正常受试者的VEP小波的眼睛间比较； 传入视神经VEP波群变化的测定 传导障碍；VEP子波变化的测定 糖尿病视网膜病变。ERG和VEP信号将被记录下来并由计算机 使用最新开发的数字滤波技术进行分析。灯 将仔细校准和控制刺激物。HIGH的记录 频率VEP小波似乎表现出明显的优势 枕部较慢(低频)波的传统记录 头皮，其中最主要的是测量精度相对较高 高峰潜伏期。

In the previously funded period, I have succeeded in achieving stimulation and recording conditions which allow for the repeated and reliable recording of light evoked high frequency wavelets ("oscillatory potentials"), which are obtained from the occipital scalp in man. The specific aims of this project are directed toward further understanding of the characteristics and origins of light evoked electrophysiological activity of the human visual system, and toward the application of these measures to the diagnosis of visual system anomalies and disease. The following plan is proposed to achieve these aims: Phase I: Investigation of the development of VEP wavelets in newborns and infants. Included in Phase I will be a comparison of the developmental sequence of occipital VEP wavelets and slow waves; an analysis of the functions of wavelet and slow wave amplitude and implicit time as related to stimulus flash intensity; and an analysis in terms of the possible progression from subcortical to cortical visual mechanisms in the developing infant. Phase II: Investigation of specific properties and relationships of wavelets recorded at the eye (ERG) and at the scalp (VEP). Included in Phase II will be the determination of specific relationships between the various VEP wavelets and the temporally preceding electroretinogram (ERG) wavelets; investigation of the effects of different electrical reference sites upon the scalp distribution of VEP wavelets; investigation of the differences in spatial frequency tuning as reflected in the amplitude of wavelets and slow waves. Phase III: Investigation of the use of VEP wavelets for the diagnosis of visual system anomalies and disease. Included in Phase III will be inter-ocular comparisons of VEP wavelets in normal subjects; the determination of the changes in VEP wavelets in afferent optic nerve transmission deficits; and the determination of the changes in VEP wavelets in diabetic retinopathy. ERG and VEP signals will be recorded and computer analyzed, using newly-developed digital filtering techniques. Light stimuli will be carefully calibrated and controlled. The recording of high frequency VEP wavelets appears to represent significant advantages over the traditional recording of slower (lower frequency) waves from occipital scalp, chief among which is the relatively greater precision of measurement of peak latencies.