SACCADIC EYE MOVEMENT STUDIES

这项研究的长期目标是了解紧张情绪是如何 系统将感官信息翻译成启动的命令 以及眼球跳动的执行。扫视系统是 相对较好的理解，因为它的简单的外围机械 和肌肉系统，因为与眼跳相关的脑干神经元是可以接触到的， 而且因为它很容易准确地测量眼睛的运动。我们知道 神经元类型，k它们的放电模式，以及可能的连接 神经眼跳发生器。然而，我们的理解是不完整的，所以它 得到了合理的神经生理学假设的补充 以模型的形式产生工作假说，这些假说模拟 工作正常的扫视发生器。 我们将进行三组实验，以更全面地描述 扫视的产生过程。第一个实验将测试两个流行的 当前型号。这两个模型做出了截然不同的预测 关于动眼神经受损后会引起的眼跳 神经积分器。因此，我们将破坏假定的积分器和 记录眼跳的变化。这项实验将表明，该模型 正确预测产生的扫视最准确地描述了 扫视发生器。 在第二组实验中，我们将记录从假定的输入到 扫视发生器。我们将专注于定位与眼跳相关的神经元 在已知投射到眼跳发生器的中脑区域。 排放的参数将被定量地与 扫视和目标指标，以发现这些神经元是否编码 先前假设的扫视信号或必须 整合到眼跳生成的不断演变的模型中。 最后，我们将研究与中脑扫视相关的联系 神经元测试眼跳发生器中的神经元以及它们的连接 以及其他与眼跳相关的结构。我们将使用尖峰周直方图 在警觉训练中评估动物之间的功能联系 神经元。对放电特性的描述和对其的分析 功能鉴定的神经元类型之间的联系的演示 将帮助我们理解信号是如何更集中地产生的 眼球跳动。 这些研究应该会加深我们对神经系统如何 转换视觉感觉信息以产生扫视运动反应。 此外，我们和其他公司的数据已经并应该继续 BE，在神经系统的诊断和定位中非常有用 由多种原因引起的功能障碍。

The long-term objective of this research is to understand how the nervous system translates sensory information into the commands for the initiation and execution of saccadic eye movements. The saccadic system is comparatively well understood because of its simple peripheral mechanics and musculature, because saccade-related brainstem neurons are accessible, and because it is easy to accurately measure eye movements. We know the neuron types,k their discharge patterns, and may of the connections of the neural saccade generator. Our understanding is incomplete, however, so it has been supplemented with reasonable, neurophysiological assumptions to yield working hypotheses, in the form of models,, that simulate a functioning saccade generator. We will perform three sets of experiments to more completely characterize the saccade generation process. The first experiment will test two popular current models. Those two models make distinctly different predictions about the saccades that will result following damage to the oculomotor neural integrator. Therefore we will lesion the putative integrator and record the changes in saccades. This experiment will show that the model that correctly forecasts the resulting saccades most accurate describes the saccade generator. In the second set of experiments we will record from putative inputs to the saccade generator. We will concentrate on saccade-related neurons located in regions of the mesencephalon known to project to the saccade generator. The parameters of the discharge will be quantitatively compared to the saccade and target metrics in order to discover whether these neurons code previously hypothesized saccade signals or new signals that must be incorporated into evolving models of saccade generation. Finally, we will study the connections of mesencephalic saccade-related neurons t neurons in the saccade generator as well as their connections with other saccade-related structures. We will use peri-spike histograms in alert trained animals to assess the functional connections between neurons. The description of discharge characteristics and the demonstration of connections of functionally identified types of neurons will help us to understand how signals originating more centrally produce saccadic eye movements. These studies should further our understanding of how the nervous system transforms visual sensory information to generate saccadic motor responses. In addition, our data and that of other has been, and should continue to be, very useful in the diagnosis and localization of nervous system dysfunction resulting from a wide variety of causes.