The impact of Hyaluronic Acid on growth factor signalling and angiogenesis

血管发育受生长因子信号传导控制。血管被生长因子梯度吸引并沿着生长因子梯度迁移，这是由细胞外基质（ECM）控制的。从斑马鱼模型，我们已经确定了一个新的基因，调节ECM，影响生长因子信号和血管发育。该项目将探索这种基因影响信号的机制。它将全面定义胚胎中需要它的位置，并研究它与哪些辅因子相互作用以执行其功能。使用遗传斑马鱼和小鼠模型以及细胞培养模型，我们将研究该基因的基本生物学。

Blood vessel development is controlled by growth factor signalling. Vessels are attracted by and migrate along growth factor gradients, and this is controlled by the extracellular matrix (ECM). From the zebrafish model, we have identified a novel gene that modulates the ECM, impacting growth factor signalling and vessel development. The project will explore by what mechanism this gene impacts signalling. It will comprehensively define where in the embryo it is required and investigate what cofactors it interacts with to perform its function. Using genetic zebrafish and mouse models as well as cell culture models we will investigate the fundamental biology of this gene.