How inhibition shapes human brain oscillations and working memory capacity

本项目旨在研究抑制机制、伽马振荡和人类工作记忆之间的联系。在短期“工作”记忆中保留信息对认知至关重要，影响我们的个性和智力。然而，这一过程背后的大脑机制尚不清楚。来自动物/计算研究的证据表明，依赖于神经抑制的高频“伽马”波段的大脑振荡对工作记忆至关重要。绘制从分子到认知的路径将详细说明神经机制如何塑造人类的行为表现，并指导增强记忆和认知功能的努力。

This project aims to investigate the link between inhibitory mechanisms, gamma oscillations and working memory in humans. Retaining information in short-term ‘working’ memory is crucial for cognition, influencing our personality and intelligence. However, the brain mechanisms underlying this process are unclear. Evidence from animal/computational research indicates that brain oscillations in high frequency ‘gamma’ bands, which depend on neural inhibition, are critical for working memory. Mapping a path from molecules to cognition will detail how neural mechanisms shape human behavioural performance and guide efforts to enhance memory and cognitive function.