A DYNAMIC AND FLEXIBLE MANUFACTURING PLATFORM: INTENSIFYING BIOCATALYSIS FOR FRAGRANCE AND API PRODUCTION

化学家可以制造新的化合物和材料，但合成方法的工具必须不断扩展和改进，以实现化合物和材料的可持续生产，因为社会对新的或改进的药物和其他化合物的需求很高。满足这一需求的环境友好型进程将在许多方面提高生活质量。在我们提出的研究计划中，我们将介绍一种在反应过程中混合溶液的新方法。这种高性能混合的好处很多，缩短了反应时间，因此可以设想更高的生产率，我们已经在初步实验中证明了这一点。在与一家中小型企业公司Bioextractions Wales的密切合作下，我们计划使用这种方法合成香料分子。在建立了原则并采取了第一步，以高档的一些过程的帮助下，较大的设备可在BioExtractions威尔士，我们将扩大使用生物催化过程的化合物（API的）的生产所需的药物分子的合成。此外，这些技术要求更高的反应将在公司的现场大规模进行。此外，我们将研究混合的“强度”以及与酶促反应结果的关系，然后通过反应混合物的在线分析进行进一步的自动优化。这一切都将支持本提案的总体目标，即开发新的有效工艺，以环境友好和节约资源的工业规模合成用作香料的化合物和合成药物。

Chemists can make novel compounds and materials, but the tools of synthetic methodology must be continuously expanded and improved for the sustainable production of compounds and materials as the needs from society for new or improved medicines and other compounds are high. Environmentally benign processes to satisfy that demand will increase the quality of life in many aspects. In our proposed research program, we will introduce a new method for mixing solutions during a reaction. The benefits of such high-performance mixing are numerous, shortened reaction times and therefore much higher productivities are envisioned which we could already demonstrate during preliminary experiments. In close collaboration with an SME company, Bioextractions Wales, we plan to synthesise fragrance molecules using this approach. After having established the principle and taken first steps to upscale some of the processes with the help of larger equipment available at BioExtractions Wales, we will extend the use of biocatalytic processes to the production of compounds (API's) necessary for the synthesis of drug molecules. Also, these technically more demanding reactions will be performed on a large scale at the companies' site. In addition, we will investigate the 'strength' of mixing and the relation to the outcome of the enzymatic reactions, before introducing further and automated optimisation through inline analysis of the reaction mixtures. This will all support the overall target of this proposal, which is the development of new and efficient processes for the environmentally friendly and resource-cautious industrial-scale synthesis of compounds used as fragrances and for the synthesis of drugs.