NEW ASYMMETRIC PROCESSES FOR USE IN ORGANIC SYNTHESIS

这项研究旨在发现和开发新的不对称过程 在包括药物在内的光学纯有机物质合成中的应用 和维他命。 重点介绍了不对称烯烃氧化过程，但不对称 刘易斯酸催化的反应也将被研究。所有的 要研究的过程是金属催化的或金属中介的，并且所有的 涉及手性配体。 钛催化不对称环氧化反应机理的研究 相关进程将继续进行。将作出特别努力，以 获得不同钛配合物的X-射线晶体结构 酒石酸衍生物配体。这些机械论研究的主要目的是 以确保从这些新催化剂和试剂中获得最大利益 有机合成领域。 将合成具有C2和C3对称性的新型手性配体 以及它们在不对称合成中的应用。 通向小手性合成子的有效不对称氧化途径将是 被追寻。缩水甘油醇和甘油醛的等价物将是主要目标。

This research seeks to discover and develop new asymmetric processes for use in the synthesis of optically pure organic substances including drugs and vitamins. Emphasis is placed on asymmetric olefin oxidation processes, but asymmetric Lewis acid-catalyzed reactions will also be investigated. All of the processes to be studied are metal-catalyzed or metal-mediated, and all involve chiral ligands. Studies on the mechanism of the titanium-catalyzed asymmetric epoxidation and related processes will continue. A special effort will be made to obtain X-ray crystal structures of complexes of titanium with various tartrate-derived ligands. The primary aim of these mechanistic studies is to ensure maximum benefit from these new catalysts and reagents for the field of organic synthesis. New classes of chiral ligands having C2 and C3 symmetry will be synthesized and their applications in asymmetric synthesis investigated. Efficient asymmetric oxidation routes to small chiral synthons will be sought. Glycidol and glyceraldehyde equivalents will be primary targets.