GENETIC CONTROL OF MAMMALIAN DIFFERENTIATION

这项研究项目涉及哺乳动物发育的问题。 遗传学。它特别关注的是确定 特定的基因，包括结构和调控基因，控制着不同的 胚胎发育和细胞分化水平上的一些方面 形态发生和生物化学。小鼠的突变会影响 发展和分化是这些研究的工具。这个 基因导致的特定发育缺陷的鉴定 提供了阐明相应的正常机制的可能性 他们的发育和基因控制。特别关注的焦点是 复杂的基因，例如T-基因座和几个致命的白化病缺失 老鼠。后者似乎包括一系列相关的调节基因 具体地说，就是控制肝细胞分化。方法： 遗传学、发育生物学、生物化学、体细胞遗传学、 电子显微镜、细胞学和分子生物学为这些研究服务。 本研究为生育研究提供了模型系统。 人类新陈代谢的缺陷和先天错误。它打开了新的视野 论先天畸形的病因学与遗传学 外观相似的情况的异质性，例如糖原储存 疾病。

This research project deals with problems of mammalian developmental genetics. In particular it is concerned with the identification of specific genes, both structural and regulatory, which control various aspects of embryonic development and cell differentiation on levels of morphogenesis and biochemistry. Mutations in the mouse affecting development and differentiation serve as tools in these studies. The identification of genetically caused specific developmental defects provides the potential of elucidating the corresponding normal mechanisms of development and their genetic control. Particular attention centers on complex genes, e.g. the T-locus and several lethal albino deletions in the mouse. The latter appear to include a series of regulatory genes concerned specifically with the control of liver cell differentiation. Methods of genetics, developmental biology, biochemistry, somatic cell genetics, electronmicroscopy, cytology and molecular biology serve these studies. The research proposed here provides model systems for the study of birth defects and inborn errors of metabolism in humans. It opens up new views on the etiology of congenital malformations and underscores the genetic heterogeneity of conditions with similar appearances, e.g. glycogen storage diseases.