Does muscle contribute to the maintenance of vitamin D status in winter?

该项目旨在测试在冬季低投入时维持维生素D状态的机制。维生素D代谢物25-羟基维生素D [25（OH）D]在血液中的半衰期较长，在冬季保持足够的维生素D状态，此时在皮肤中产生维生素D的阳光减少。根据绵羊和老鼠的初步数据，该项目提出骨骼肌而不是脂肪储存维生素D。该项目将在绵羊、培养的肌肉细胞和转基因小鼠中测试这一假设。该项目将确认骨骼肌中确定的过程是否有助于维持维生素D状态，并确定增强这一过程的方法。

This project aims to test the mechanism by which vitamin D status is maintained in winter when input is low. The long half-life in blood of the vitamin D metabolite, 25-hydroxyvitamin D [25(OH)D], maintains an adequate vitamin D status over winter, when sunlight, which produces vitamin D in skin, is reduced. From preliminary data in sheep and mice, this project proposes that skeletal muscle, not fat, stores vitamin D. This project will test this hypothesis in sheep, cultured muscle cells and in transgenic mice. The project will confirm whether the processes identified in skeletal muscle contribute to the maintenance of vitamin D status, and identify ways of enhancing this process.