DELETERIOUS MICROALGAL TOXINS

建议的工作是阐明其化学和药理性质。 对公众有严重影响的藻类和其他水生毒素 健康，并提供设计预防措施所需的基本信息 措施，同时它打算发现新的特定于站点的 毒素作为研究重要生物机制的工具 阐明神经的结构和功能的终极意图 受体SuH作为钠通道。具体地说，隔离、结构 麻风性贝类的检测及药理评价 毒物(PSP)及相关毒素的发现。及其他 生物，2)佛罗里达州生产的神经毒性贝类毒素(NSP) 赤潮生物，短裸甲藻，3)赤潮生物中的肝毒素 蓝绿藻，铜绿微囊藻，有时威胁公众 水系统，4)一种参与其中的不明毒素 计划在纽约和新英格兰发生贝类中毒事件。 毒素将从大规模培养的生物体和/或 在食物链中积累毒素的有机体。药理作用 并对分离出的毒素进行神经生理学研究 与专家合作。派生出的知识将是 向卫生官员和其他有关方面传播。

The proposed work is to elucidate the chemical and pharmacological nature of algal and other aquatic toxins which have serious impact on public health and provide basic information required to design preventive measures, and at the same time it is intended to discover new site-specific toxins as tools to investigate important biological mechanisms with an ultimate intention to elucidate the structure and function of neural receptors suh as sodium channels. Specifically, the isolation, structure determination and pharmacological evaluation of 1) paralytic shellfish poisons (PSP) and related toxins found in Gonyaulax spp. and other organisms, 2) neurotoxic shellfish poisons (NSP) produced by the Florida red tide organisms, Gymnodinium breve, 3) the hepatotoxins in the blue-green alga, Microcystis aeruginosa, which sometimes threatens public water systems, 4) an unidentified toxin which was involved in the mass shellfish poisoning in New York and New England, are planned. The toxins will be isolated from the mass-cultured organisms and/or those organisms which accumulated the toxins in the food chain. Pharmacological and neurophysiological studies of the isolated toxins will be carried out in collaboration with specialists. The derived knowledge will be disseminated to health officials and other concerned parties.