DRUG ANALYSIS BY ION MOBILITY SPECTROMETRY

用气体分析复杂混合物，如生物液体 色谱法通常需要使用选择性检测器 歧视干扰物种和/或增强对 所需的化合物。 然而，除了质谱仪之外，大多数 GC检测器在宽范围内难以或不可能操作。 多种选择性和非选择性模式。 虽然不是为了 提供质谱仪提供的数据的范围和范围，离子 迁移率谱仪能够定量和低分辨率 定性检测有机化合物。 当与普通 采用选择性检测器，如电子捕获和 氮磷探测器，离子迁移谱仪提供了 可调选择性的独特优势。 由于其多功能性和 与质谱仪相比，该仪器成本低， 在生物样品中常规筛选许多药物的巨大潜力。

The analysis of complex mixtures such as biological fluids by gas chromatography often requires the use of selective detectors to discriminate against interfering species and/or enhance the response to desired compounds. However, with the exception of mass spectrometers, most GC detectors are either difficult or impossible to operate in a wide variety of selective and nonselective modes. Although not designed to provide the range and scope of data provided by mass spectrometers, the ion mobility spectrometer is capable of quantitative and low resolution qualitative detection organic compounds. When compared with commonly employed selective detectors such as the electron capture and nitrogen-phosphorus detectors, the ion mobility spectrometer offers the distinct advantage of tunable selectivity. Because of its versatility and low cost when compared to that of mass spectrometers, the instrument has great potential for routine screening of many drugs in biological samples.