Mass Spectrometry Method for Carbohydrate Structure

碳水化合物结构的质谱分析方法

• 批准号: 7628332
• 负责人: HERBERT H HILL
• 金额: $ 30.34万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-28 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7628332
• 关键词: Atmospheric Pressure; Carbohydrates; Complex; Coupled; Dissociation; Electrospray Ionization; Gases; Glycosides; Individual; Injection of therapeutic agent; Investigation; Ions; Isomerism; Link; Literature; Manuscripts; Mass Fragmentography; Mass Spectrum Analysis; Methods; Monosaccharides; Nature; Oligosaccharides; Phase; Physiologic pulse; Positioning Attribute; Publications; Reporting; Research; Research Personnel; Shapes; Source; Spectrometry; Structure; Suggestion; Vertebrates; adduct; base; carbohydrate structure; human subject; improved; instrument; ion mobility; mass spectrometer; monomer; novel; programs; research study; success; sugar; tool

3 oaae.s) 1Z_ Introduction to SuoDlemental Aoolication (Not to exceed one oaoe) A. SoecificAims ^R-21^ B. Backaround and Sianificance 2J C. Preliminary Studies 2pound D. Research Desian and Methods (R-21) 29 Milestones (R-2V __M__ A. Soecific Aims (R-33) 35 D. Research Desian and Methods (R-33^ 3pound H. Human Subjects 44 I. Vertebrate Animals 44 J. Literature Cited 45 K. Consortium/ContractualArranaements 5J_ Checklist 54 Appendix (Five collated sets. Nopage numbering necessary for Appendix ) Check if Appendix is Appendices NOT PERMITTED forPhase I SBIR/STTR unless specifically solicited. Included Number of publications and manuscripts accepted for publication (not to exceed 10) Other items (list): PHS 398 (Rev. 05/01) Page 3 Form Page 3

3个oaae.s）1 Z_ 心理学导论（不超过一个oaoe） A. R-21的具体目标 B。Backaround和Sianificance 2 J C.初步研究2磅 D.研究设计和方法（R-21）29 米隆（R-2 V__M__） A.（R-33）35 D.研究设计和方法（R-33^3磅 H.人类受试者44 I.脊椎动物44 J.引用文献45 K.联合体/合同安排5 J_ 清单54 附录（五个整理集。附录所需的页码编号） 阑尾是 附录不允许用于I期SBIR/STTR，除非特别要求。包括 接受出版的出版物和手稿数量（不超过10份） 其他项目（列表）： PHS 398（修订版05/01）第3页表格第3页

项目成果

Ion mobility mass spectrometry analysis of isomeric disaccharide precursor, product and cluster ions.

• DOI: 10.1002/rcm.6720
• 发表时间: 2013-12-15
• 期刊: RAPID COMMUNICATIONS IN MASS SPECTROMETRY
• 影响因子: 2
• 作者: Li, Hongli;Bendiak, Brad;Siems, William F.;Gang, David R.;Hill, Herbert H., Jr.
• 通讯作者: Hill, Herbert H., Jr.

Carbohydrate structure characterization by tandem ion mobility mass spectrometry (IMMS)2.

• DOI: 10.1021/ac303273z
• 发表时间: 2013-03-05
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Li, Hongli;Bendiak, Brad;Siems, William F.;Gang, David R.;Hill, Herbert H., Jr.
• 通讯作者: Hill, Herbert H., Jr.

Ion mobility-mass spectrometry analysis of isomeric carbohydrate precursor ions.

• DOI: 10.1007/s00216-009-2865-y
• 发表时间: 2009-08
• 期刊: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
• 影响因子: 4.3
• 作者: Zhu, Maolei;Bendiak, Brad;Clowers, Brian;Hill, Herbert H., Jr.
• 通讯作者: Hill, Herbert H., Jr.

Resolving structural isomers of monosaccharide methyl glycosides using drift tube and traveling wave ion mobility mass spectrometry.

• DOI: 10.1021/ac203116a
• 发表时间: 2012-04-03
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Li, Hongli;Giles, Kevin;Bendiak, Brad;Kaplan, Kimberly;Siems, William F.;Hill, Herbert H., Jr.
• 通讯作者: Hill, Herbert H., Jr.

An assessment of computational methods for obtaining structural information of moderately flexible biomolecules from ion mobility spectrometry.

对从离子淌度光谱法获取适度柔性生物分子结构信息的计算方法进行评估。

• DOI: 10.1007/s13361-012-0339-5
• 发表时间: 2012
• 期刊: Journal of the American Society for Mass Spectrometry
• 影响因子: 3.2
• 作者: Zakharova,NataliaL;Crawford,ChristinaL;Hauck,BrianC;Quinton,JacobK;Seims,WilliamF;HillJr,HerbertH;Clark,AuroraE
• 通讯作者: Clark,AuroraE