Integrated bioreactor platform for rapid scale-up and translation

为了实现英国政府的可持续性和清洁增长目标，显然需要从原油衍生的石化产品转向利用可再生资源生产的生物基替代品。为了解决这一问题，迫切需要生物制造路线，以消除化学品生产对化石燃料衍生原材料的依赖。这一目标是英国工研院国家工程生物学计划的核心主题，即清洁增长、循环经济的起源和温室气体(GHG)排放的减少，所有这些都被载入英国政府工业战略的净零/清洁增长目标。这种从依赖石化产品到可持续生物制造的转变在技术准备水平(TRL)上带来了重大挑战。工业向清洁和循环生物经济的过渡与低TRL的创新相联系，拟议的生物反应器平台将促进向更高TRL的过渡，提供从学术发现到过程验证的关键一步。新平台将建立在英国政府对UOM托管的卓越中心的重大战略投资的基础上，并进一步支持曼彻斯特作为英国可持续化学品制造的中心，利用生物催化和合成生物学方面的卓越优势，并将其与生化工程和发酵过程开发专业知识相结合，以实现成功的放大和工业转化。所要求的集成生物反应器平台将填补英国工艺开发和放大能力方面的公认空白，并将支持技术上可行和经济上可行的生物基础化学品生产的可扩展工艺的工程开发。为了实现这一目标，生物反应器平台将提供跨越小规模并行发酵的能力，用于快速筛选和实验室台式生物工艺开发，以扩大规模并进行工艺设计和优化。生物反应器平台在研究翻译方面的进步和商业化机会的增加将促进从化石转向生物基化学品，为日常生活中使用的产品提供一条可再生的途径。

In order to meet the UK Government's sustainability and clean growth targets there is a clear need for a switch from crude oil derived petrochemicals to biobased alternatives produced from renewable resources. To address this sustainable biomanufacturing routes are urgently required to remove the dependence of chemicals production on fossil fuel derived raw materials. This goal is central to the UKRI National Engineering Biology Programme theme of Clean Growth and the genesis of a Circular Economy and reduction of Greenhouse Gas (GHG) emissions, all of which are enshrined in Net Zero/Clean Growth targets in the UK Government's Industrial Strategy. This transition from a reliance on petrochemicals to sustainable biomanufacturing presents major challenges across Technology Readiness Levels (TRLs). Industrial transition to a Clean and Circular Bioeconomy is linked to innovations at low TRL, the proposed bioreactor platform will facilitate the transition to higher TRLs, providing a key step to pull through academic discovery to process verification. The new platform will build on major strategic UK government investments in UoM hosted Centres of Excellence, and further support Manchester as the UK epicentre for sustainable chemicals manufacturing, leveraging excellence in biocatalysis and synthetic biology, and combining this with biochemical engineering and fermentation process development expertise for successful scale up and industrial translation.The requested integrated bioreactor platform will fill a recognised gap in the UK's process development and scale up capability and will support the engineering development of scalable processes for technically feasible and economically viable biobased chemicals production. To achieve this the bioreactor platform will provide capability spanning small-scale parallel fermentation for quick screening and lab benchtop bioprocess development to scale up and process design and optimisation. The advances in research translation and the increase in commercialisation opportunities enabled by the bioreactor platform will facilitate the switch from fossil to bio-based chemicals, providing a renewable route to the products used in daily life.