NATURAL PRODUCT SYNTHESIS VIA EPISULFONIUM ION INITIATED

目标将是开发改进的化学合成方法，用于 具有生物意义的天然产物及其结构类似物。 这些合成注定要依靠新的程序来实现 环硫正离子引发的碳环反应是我们最近所做的 被发现了。目标为合成的特定分子包括 抗癌药物紫杉酮和吗啡类镇痛剂。 细胞毒素紫杉二酮在体内具有显著的抗肿瘤活性。 大鼠Walker肌内癌肉瘤256及其体外抗细胞作用 来源于人类鼻咽癌(KB)。 镇痛剂吗啡及其类似物具有丰富的临床使用历史 用于缓解因身体创伤和慢性疾病引起的剧烈疼痛 疾病。 除上述目标外，硫离子的利用 乙烯基环丙烷与高阶多烯的促进环化反应 将对引发剂进行综合评价。

The objectives will be to develop improved chemical syntheses for biologically significant natural products and their structural analogs. These syntheses are destined to rely upon new procedures for effecting episulfonium ion initiated carboannulations which we have recently discovered. Specific molecules targeted for synthesis include the anti-cancer agent taxodione and the morphinan analgesics. The cytotoxin taxodione has exhibited significant activity in vivo against Walker intramuscular carcinsarcoma 256 in rats and in vitro against cells derived from human carcinoma of the nasopharnyx (KB). The analgesic morphine and its analogs have a rich history of clinical use for the relief of severe pain resulting from physical trauma and chronic illnesses. In addition to the above objectives, the utilization of sulfenium ion promoted cyclizations involving vinylcyclopropane and higher order polyene initiators will be synthetically evaluated.