TRANSPORT OF IGG ANTIBODIES THROUGH THE PLACENTA

这个项目是我们正在进行的运输研究的继续 母体抗胎儿抗体通过人胎盘和 胎盘外膜。基本的工作原理是免疫球蛋白附着在 与滋养细胞和羊膜上皮细胞上的Fc受体特异性结合，是 内化并穿透到膜的另一侧。AS 免疫球蛋白通过胎儿的纤维基质抗体扩散。 抗原与抗原形成络合物，被特异性地吸附到 巨噬细胞Fc受体，内吞并降解。的其余部分 完整运输的免疫球蛋白进入胎儿血液或羊水。这 该提案旨在通过以下方式证明抗原抗体复合体的存在 鉴定抗原并建立抗体特异性。此外，它还 旨在表征滋养层Fc受体，研究其吸附作用 Fc受体阳性的羊膜/滋养层细胞的内吞作用 一种新型人免疫球蛋白在体外转运途径的确定 运输系统。这将是第一次有可能 无论是在体内还是在体外，观察免疫球蛋白在人体内的转运机制。

This project is a continuation of our ongoing study of the transport of maternal anti-fetal antibodies through the human placenta and extraplacental membranes. The basic operating theory is that IgG attaches specifically to Fc receptors on trophoblast and amnionic epithelium, is internalized and passed through to the opposite side of the membrane. As the IgG is diffusing through the fibrous stroma antibodies to fetal antigens form complexes with antigen, are specifically adsorbed to macrophage Fc receptors, endocytosed and degraded. The remainder of the intact transported IgG passes into the fetal blood or amniotic fluid. This proposal is designed to prove the presence of antigen antibody complexes by indentifying antigen and establishing antibody specificity. Moreover, it is designed to characterize the trophoblastic Fc receptor, study adsorptive endocytosis by Fc receptor positive amnionic/trophoblastic cells and determine the route of IgG transport in a novel in vitro human IgG transport system. This will be the first time that it has been possible to look at mechanisms of IgG transport in the human either in vivo or in vitro.