OpenBioMAPS: shared tools for accelerating UK bio-manufacturing

我们将开发一个开源工具生态系统，以加速英国生物制造业采用工程生物学能力。知识产权保护允许生物企业自由经营，防止不公平竞争。然而，大多数工程生物系统需要许多“螺母和螺栓”部件。初创企业和中小企业，谁是通过新的可持续制造工艺推进英国清洁增长目标的关键，有有限的访问相比，成熟的公司，可能需要谈判的许可证的灌木丛.开放许可证可以降低交易成本，在采用新的创新中小企业的，因为我们在OpenPlant研究中心证明.我们现在将扩展我们以前的工作，开发用于植物和微生物工程的DNA工具包（openplant.org），用于材料共享的法律的工具（OpenMTA. org）以及工程和生物学培训（例如biomaker.org）。我们计划开发（i）英国生物制造公司的生物工程工具，包括微生物发酵和基于植物叶绿体的生物生产的原型和商业化的机会，（ii）为学者和行业科学家提供培训，以发展生物学和工程学接口的技能; iii）英国工程生物学界的小型项目，以促进工具的进一步发展。总体而言，这将建设采用开放源码工具、原则和开发做法的能力。开放源码工具在计算领域很普遍，行业估计表明，80-90%的新应用程序是从现有组件构建的，其中大部分是开放源码。生物制造可以从类似的可重用性中受益。我们的目标是建立一个旗舰平台，以加速英国生物制造企业的发展，并为英国工程生物学建立一个开源项目办公室（OSPO）提供可能的跳板，以反映成功的科技行业OSPO。

We will develop an ecosystem of open source tools to accelerate adoption of engineering biology capabilities in the UK biomanufacturing sector. IP protection allows bioenterprises freedom to operate and prevent unfair competition. However, most engineered biosystems require many "nuts- and-bolts" parts. Start-ups and SMEs, who are critical to advance UK clean growth targets through novel sustainable manufacturing processes, have limited access compared to established companies and may need to negotiate a thicket of licences.Open licensing can reduce transaction costs in adoption of new innovations by SME's, as we demonstrated in the OpenPlant research centre. We will now expand our previous work developing DNA toolkits for plant and microbial engineering (openplant.org), legal tools for materials sharing (OpenMTA.org) and training for engineering and biology (e.g. biomaker.org). We plan to develop (i) biological engineering tools for UK bio-manufacturing companies including prototypes for microbial fermentation and plant chloroplast-based bioproduction and opportunities for commercialisation, (ii) training for academics and industry scientists to develop skills at the interface of biology and engineering; iii) mini-projects across the UK engineering biology community to promote further development of tools. Overall, this will build capacity for adoption of open source tools, principles and development practices.Open source tools are pervasive in computing, industry estimates suggest that 80-90% of new apps are built from existing components, mostly open source. Biomanufacturing could benefit from similar reusability. We aim to establish a flagship platform to accelerate the UK biomanufacturing enterprise, and a possible springboard for establishing an Open Source Program Office (OSPO) for UK engineering biology, mirroring successful tech industry OSPOs.