Tackling animal & zoonotic infections together

传染病严重影响养殖动物的生产力和福利，威胁可持续农业和全球粮食安全。此外，从养殖动物传播给人类的人畜共患病造成了高昂的社会和经济代价，并具有大流行的可能性。这些挑战与我们这个时代的许多最紧迫的问题交织在一起，包括抗生素耐药性的上升以及畜牧业对气候和环境的影响。此外，随着病原体的进化逃避了疫苗介导的免疫力，药物变得不那么有效，动物和人畜共患病的控制正变得越来越具有挑战性。我们提供独特的基础设施，专业知识和资源，并在整个研究和创新系统中建立了深厚的联系。我们的组织在培训应对动物和人畜共患感染所需的下一代科学家、技术专家和研究专业人员方面具有全球重要意义。在这样做的时候，我们解决的技能和能力，由UKRI定义为脆弱的。我们将利用这一地位促进跨部门和跨学科的知识交流和合作。特别是，我们将利用与企业的广泛合作网络，（特别是动物制药和育种公司）和公共或第三部门组织，以提高孔隙率和发展不同类型和职业阶段的员工，包括那些支持研究的员工（例如业务发展、法律的建议、动物使用、生物安全、设施管理等）我们组织的研究优势包括，但不限于：关于宿主-病原体相互作用的世界级基础研究，以设计新的或改进的疾病控制解决方案。（由我们的联合免疫学联盟和国际兽医疫苗学网络提供支持）。疫苗生产和平台技术的创新（例如Pirbright的兽医疫苗创新和制造中心）。与育种公司合作，选择性地培育对传染病具有更强抵抗力或复原力的动物。工程生物学，赋予对传染病的抵抗力（例如通过基因组编辑或转基因）。开发抗生素的替代品。开发用于快速检测病原体和耐药性的特异性和敏感性诊断测试。研究传染病的新3R方法。追踪新病原体的演变和传播，并对干预措施的影响进行建模。使用人工智能来预测新兴病原体的趋向性和风险。我们与企业的广泛合作伙伴关系为在全球范围内实施进步提供了一条关键途径。此外，我们与低收入和中等收入国家的公共和第三部门组织合作，为小农提供收益，以减轻贫困和营养不良（例如与国际畜牧研究所合作）。

Infectious diseases profoundly affect the productivity and welfare of farmed animals and threaten sustainable agriculture and global food security. Moreover, zoonoses that transmit to humans from farmed animals exert high societal and economic costs and have pandemic potential. These challenges intersect with many of the most urgent issues of our era, including the rise of antimicrobial resistance and impacts of animal agriculture on the climate and environment. Moreover, control of animal and zoonotic diseases is becoming more challenging as pathogens evolve to escape vaccine-mediated immunity and drugs become less effective.This proposal brings together two BBSRC-sponsored Institutes that offer national capability to combat animal and zoonotic diseases. We offer unique infrastructure, expertise and resources and have deep connections across the research and innovation system. Our organisations are globally important in training the next generation of scientists, technical specialists and research professionals needed to tackle animal and zoonotic infections. In doing so, we address skills and capacities defined by UKRI as vulnerable. We will harness this position to catalyse knowledge exchange and collaboration, both across sectors and disciplines. In particular, we will use our extensive network of collaborations with businesses (particularly animal pharmaceutical and breeding companies) and public or third sector organisations to enhance porosity and develop staff of diverse types and career stages, including those who support research (e.g. in business development, legal advice, animal use, biosafety, facility management, etc)Research strengths our organisations include, but are not limited to:World-class fundamental research on host-pathogen interactions to design new or improved solutions for disease control.Development & evaluation of veterinary vaccines (supported by our joint Immunological Toolbox & International Veterinary Vaccinology Network).Innovation in vaccine manufacture & platform technologies (e.g. Centre for Veterinary Vaccine Innovation & Manufacturing at Pirbright).Selective breeding of animals with enhanced resistance or resilience to infectious diseases in partnership with breeding companies.Engineering Biology to confer resistance to infectious diseases (e.g. via genome editing or transgenesis).Development of alternatives to antibiotics.Development of specific & sensitive diagnostic tests for rapid detection of pathogens & drug resistances. Novel 3Rs approaches to study infectious diseases. Tracing the evolution & spread of novel pathogens & modelling the impact of interventions.Use of Artificial Intelligence to predict the tropism & risk of emerging pathogens. Our extensive partnerships with businesses provide a key route to implement advances at global scale. Moreover, we partner with public and third sector organisations in low- and middle-income countries to deliver gains for smallholder farmers to alleviate poverty and malnutrition (e.g. in collaboration with the International Livestock Research Institute).