IMMUNOREGULATION IN PREGNANCY

这是一项继续研究局部免疫作用的建议。 预防母体抗胎儿免疫排斥反应的调控。这个 潜在的理由是，该系统有时可能会失败，导致 自然流产。了解这些机制可能对 减少此类故障的发生率。其运作原理是 对发育中的胚胎的保护是由以下因素共同作用的结果 滋养细胞提供的免疫惰性物理屏障和 在子宫周围产生的局部免疫抑制区域 胎儿。这种环境是在蜕膜反应过程中通过 前列腺素产生细胞数量的大量增加，主要是 巨噬细胞。为了探索这一假设，有人建议进行一项研究 执行：1)影响巨噬细胞聚集的控制机制 怀孕期间的子宫，2)机制(S)负责 蜕膜巨噬细胞的免疫调节，3)蜕膜巨噬细胞免疫调节的程度和性质 子宫区域淋巴结的免疫调节作用--4)建立子宫区域淋巴结免疫调节模型 与消炎痛人工流产密切相关的建议 免疫调节机制。上述具体目标将通过以下方式进行研究 小鼠模型系统中的各种细胞免疫技术。在……里面 结论，这些研究应该导致现有知识的扩展 孕期免疫学的研究。

This is a proposal to continue studies into the role of local immune regulation in preventing a maternal anti-fetal immune rejection. The underlying rationale is that the system may at times fail, leading to spontaneous abortion. Understanding the mechanisms may be important to decreasing the incidence of such failures. The operating theory is that protection of the developing embryo results from a combination of the immunologically inert physical barrier provided by the trophoblast and a region of local immunosuppression generated in the uterus around the fetus. This environment is generated during the decidual response through a massive increase in numbers of prostaglandin producing cells, principally macrophages. To explore this hypothesis, it is proposed that a study be performed of: 1) Control mechanisms influencing macrophage accumulation in the uterus during pregnancy, 2) Mechanism(s) responsible for immunoregulation by decidual macrophages, 3) The extent and nature of immunoregulation in uterine regional lymph nodes, 4) A model of indomethacin induced abortion which is closely relevant to the proposed immunoregulatory mechanisms. The above specific aims will be studied using a variety of cellular immune techniques in a mouse model system. In conclusion, these studies should lead to an extension of current knowledge of the immunology of pregnancy.