MALE PSEUDOHERMAPHRODITISM--BIOLOGY OF ANDROGENS

男性假两性，特别是有5个阿尔法- 还原酶缺乏和雄激素不敏感是独一无二的 自然实验，以阐明不同的作用 男性性激素(T)和双氢睾酮(DHT)的变化 分化发育及其他雄激素的调节作用 生理参数。对这些主题的拟议研究 包括：T和DHT的差异效应在 促黄体生成素分泌的负反馈控制研究 搏动性促性腺激素分泌轮廓.作用的定义 T和DHT在男性性别认同形成中的作用 T和DHT(产前和产后)在观察中的作用 认知和偏侧化的性别差异及其定义 双羟色胺对男性性力的作用。 强效竞争性氮杂小行星的进一步动物研究 降低DHT的5α-还原酶抑制剂 计划进行生产，以进一步勾勒出差异 睾酮和睾酮生物作用的研究进展 双氢睾酮与男性性别分化和发育 将进行与抗雄激素的对比研究， 氟他胺，可阻断T和DHT的作用。海流 建议包括进一步研究以确定T和DHT的作用 在前列腺的分化中；周期性地释放 促性腺激素、精子发生、睾丸下降和性行为 老鼠的行为。研究还包括对效果的评估 5α-还原酶缺乏症对儿童性分化的影响 兔子特别注意定义T和T的作用 双羟色胺在区分Wolffian管和前列腺癌中的作用 差异化。

Male pseudohermaphrodites, particularly subjects with 5 alpha- reductase deficiency and androgen insensitivity are unique experiments of nature to elucidate the differential effects of testosterone (T) and dihydrotestosterone (DHT) in male sexual differentiation and development as well as other androgen mediated physiologic parameters. The proposed studies of these subjects include; evaluation of the differential effect of T and DHT in the negative feedback control of LH secretion through studies of the pulsatile gonadotrophin secretory profile; definition of the roles of T and DHT in the formation of male gender identity, elucidation of the roles of T and DHT (prenatally and postnatally) on observed sex differences in cognition and lateralization; and definition of the role of DHT on sexual potency in the male. Further animal studies with potent competitive azasteroid inhibitors of the enzyme 5 alpha-reductase to decrease DHT production are planned to further delineate the differential effects of the biologic roles of testosterone and dihydrotestosterone in male sexual differentiation and development. Comparison studies will be carried out with the antiandrogen, flutamide, which blocks the action of both T and DHT. The current proposal includes further studies to define the roles of T and DHT in differentiation of the prostate; the cyclical release of gonadotrophins, spermatogenesis, testicular descent; and sexual behavior of the rat. Studies also include evaluation of the effect of 5 alpha-reductase deficiency on sexual differentiation in the rabbit with particular attention toward defining the role of T and DHT in differentiation of the Wolffian ducts and prostatic differentiation.