Microfluidic Electrolytic Cells for Routine Synthesis in the Pharmaceutical Industry

电解是一种避免使用化学计量和有毒/危险试剂的合成过程，通常在接近环境条件的情况下进行。此外，有大量文献表明，制药工业感兴趣的反应可以以良好的选择性进行。尽管如此，尽管有机会开发更环保的合成方法，但由于需要专业设备和专业知识，电解的使用很少。这个项目汇集了一家微流设备制造商，具有有机电合成和设备设计/开发经验的工业和学术合成有机化学家和电化学化学家，以便(a)开发适合与传统微流系统集成的用户友好型微流电解设备(b)通过优化几种转化，包括醇选择性氧化为羰基化合物，表明该设备与制药行业面临的挑战相匹配；醇的胺化反应和部分氟化反应

Electrolysis is a synthetic procedure that avoids the use of stoichiometric and toxic/hazardous reagents and is usually carried close to ambient conditions. In addition, there is an extensive literature showing that reactions of interest to the pharmaceutical industry can be carried out with good selectivity. Despite this, and the consequential opportunity to develop more environmentally acceptable synthetic methods, the use of electrolysis is rare because of the need for specialist equipment and know-how. This project brings together a manufacturer of microflow equipment, industrial and academic synthetic organic chemists and electrochemists with experience of both organic electrosynthesis and equipment design/development in order (a) to develop user friendly microflow electrolysis equipment suitable for integration with traditional microflow systems (b) to show that the equipment is well matched to the challenges found in the pharmaceutical industry by optimising several conversions including the selective oxidation of alcohols to carbonyl compounds, the amination of alcohols, and partial fluorination.